Matches in SemOpenAlex for { <https://semopenalex.org/work/W3171193279> ?p ?o ?g. }
- W3171193279 endingPage "2179" @default.
- W3171193279 startingPage "2167" @default.
- W3171193279 abstract "Abstract This study aims to describe the main cognitive and behavioral comorbidities of Dravet syndrome (DS) and Lennox–Gastaut syndrome (LGS), their impact on the health-related quality of life (QOL) of patients and their caregivers, and provide a summary of the neuropsychological tools available for the evaluation of these comorbidities. The cognitive and behavioral comorbidities in patients with DS and LGS have a profound effect on the QOL of affected individuals and their caregivers and, as patients grow, tend to surpass the impact of the seizures. DS is a genetic condition associated with loss-of-function mutations in the SCNA1 sodium channel gene; LGS is an etiologically heterogeneous condition that is often secondary to structural brain abnormalities. The first seizures associated with DS typically present in the first year of life, and developmental delay becomes progressively evident thereafter. LGS usually starts between the ages of 3 and 8 years, with cognitive impairment becoming clinically evident in most patients within 5 years from the onset. In both DS and LGS, cognitive impairment is generally moderate to severe and is often accompanied by behavioral problems such as hyperactivity and inattention. In addition to optimal seizure control, regular assessment and active management of cognitive and behavioral comorbidities are required to meet the complex needs of patients with DS or LGS." @default.
- W3171193279 created "2021-06-22" @default.
- W3171193279 creator A5010425733 @default.
- W3171193279 creator A5011534666 @default.
- W3171193279 creator A5025523642 @default.
- W3171193279 creator A5033350083 @default.
- W3171193279 creator A5052203977 @default.
- W3171193279 creator A5071249665 @default.
- W3171193279 creator A5088002448 @default.
- W3171193279 creator A5088309302 @default.
- W3171193279 date "2021-06-16" @default.
- W3171193279 modified "2023-10-17" @default.
- W3171193279 title "Comorbidities in Dravet Syndrome and Lennox–Gastaut Syndrome" @default.
- W3171193279 cites W1523420748 @default.
- W3171193279 cites W1552404367 @default.
- W3171193279 cites W1557269790 @default.
- W3171193279 cites W1671458509 @default.
- W3171193279 cites W1853642699 @default.
- W3171193279 cites W1964684758 @default.
- W3171193279 cites W1969133760 @default.
- W3171193279 cites W1976499564 @default.
- W3171193279 cites W1976948277 @default.
- W3171193279 cites W1979296345 @default.
- W3171193279 cites W1986582983 @default.
- W3171193279 cites W1991568138 @default.
- W3171193279 cites W1992583104 @default.
- W3171193279 cites W1997714962 @default.
- W3171193279 cites W2000739510 @default.
- W3171193279 cites W2008553324 @default.
- W3171193279 cites W2009964743 @default.
- W3171193279 cites W2012544459 @default.
- W3171193279 cites W2018419467 @default.
- W3171193279 cites W2019747027 @default.
- W3171193279 cites W2019789061 @default.
- W3171193279 cites W2031120330 @default.
- W3171193279 cites W2050659319 @default.
- W3171193279 cites W2071251323 @default.
- W3171193279 cites W2078196673 @default.
- W3171193279 cites W2091318514 @default.
- W3171193279 cites W2097891845 @default.
- W3171193279 cites W2102461063 @default.
- W3171193279 cites W2110804937 @default.
- W3171193279 cites W2111112924 @default.
- W3171193279 cites W2111114355 @default.
- W3171193279 cites W2128780156 @default.
- W3171193279 cites W2136509920 @default.
- W3171193279 cites W2137728866 @default.
- W3171193279 cites W2140968331 @default.
- W3171193279 cites W2149377521 @default.
- W3171193279 cites W2157598171 @default.
- W3171193279 cites W2157702138 @default.
- W3171193279 cites W2162288300 @default.
- W3171193279 cites W2166662667 @default.
- W3171193279 cites W2170194739 @default.
- W3171193279 cites W2176199282 @default.
- W3171193279 cites W2192814739 @default.
- W3171193279 cites W2236656442 @default.
- W3171193279 cites W2284168487 @default.
- W3171193279 cites W2290620956 @default.
- W3171193279 cites W2398625550 @default.
- W3171193279 cites W2441225815 @default.
- W3171193279 cites W2469144905 @default.
- W3171193279 cites W2510527748 @default.
- W3171193279 cites W2513406030 @default.
- W3171193279 cites W2534591800 @default.
- W3171193279 cites W2583598024 @default.
- W3171193279 cites W2586623809 @default.
- W3171193279 cites W2592509339 @default.
- W3171193279 cites W2602302480 @default.
- W3171193279 cites W2623102212 @default.
- W3171193279 cites W2670295943 @default.
- W3171193279 cites W2734604945 @default.
- W3171193279 cites W2736365965 @default.
- W3171193279 cites W2760749448 @default.
- W3171193279 cites W2763605737 @default.
- W3171193279 cites W2766028940 @default.
- W3171193279 cites W2766832340 @default.
- W3171193279 cites W2767422484 @default.
- W3171193279 cites W2767480397 @default.
- W3171193279 cites W2767753219 @default.
- W3171193279 cites W2777385409 @default.
- W3171193279 cites W2783740041 @default.
- W3171193279 cites W2785059893 @default.
- W3171193279 cites W2789312085 @default.
- W3171193279 cites W2803976955 @default.
- W3171193279 cites W2888770928 @default.
- W3171193279 cites W2892753370 @default.
- W3171193279 cites W2893461317 @default.
- W3171193279 cites W2896604703 @default.
- W3171193279 cites W2898394960 @default.
- W3171193279 cites W2898771965 @default.
- W3171193279 cites W2903291583 @default.
- W3171193279 cites W2904357110 @default.
- W3171193279 cites W2908592573 @default.
- W3171193279 cites W2918826384 @default.
- W3171193279 cites W2920452733 @default.
- W3171193279 cites W2935390977 @default.
- W3171193279 cites W2939502226 @default.