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- W3171236705 abstract "Novel coronavirus disease 2019 (COVID-19) has spread across the globe; and surprisingly, no potentially protective or therapeutic antiviral molecules are available to treat severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection. However, zinc (Zn) and copper (Cu) have been shown to exert protective effects due to their antioxidant, anti-inflammatory, and antiviral properties. Therefore, it is hypothesized that supplementation with Zn and Cu alone or as an adjuvant may be beneficial with promising efficacy and a favorable safety profile to mitigate symptoms, as well as halt progression of the severe form of SARS-CoV-2 infection. The objective of this review is to discuss the proposed underlying molecular mechanisms and their implications for combating SARS-CoV-2 infection in response to Zn and Cu administration. Several clinical trials have also included the use of Zn as an adjuvant therapy with dietary regimens/antiviral drugs against COVID-19 infection. Overall, this review summarizes that nutritional intervention with Zn and Cu may offer an alternative treatment strategy by eliciting their virucidal effects through several fundamental molecular cascades, such as, modulation of immune responses, redox signaling, autophagy, and obstruction of viral entry and genome replication during SARS-CoV-2 infection." @default.
- W3171236705 created "2021-06-22" @default.
- W3171236705 creator A5002171894 @default.
- W3171236705 creator A5002401596 @default.
- W3171236705 creator A5043443922 @default.
- W3171236705 creator A5051758294 @default.
- W3171236705 creator A5054197081 @default.
- W3171236705 creator A5070166361 @default.
- W3171236705 creator A5084376092 @default.
- W3171236705 date "2021-08-01" @default.
- W3171236705 modified "2023-09-26" @default.
- W3171236705 title "Potential molecular mechanisms of zinc- and copper-mediated antiviral activity on COVID-19" @default.
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