Matches in SemOpenAlex for { <https://semopenalex.org/work/W3171363941> ?p ?o ?g. }
- W3171363941 endingPage "16873" @default.
- W3171363941 startingPage "16869" @default.
- W3171363941 abstract "Abstract Epigenetic programming of cells requires methylation of deoxycytidines (dC) to 5‐methyl‐dC (mdC) followed by oxidation to 5‐hydroxymethyl‐dC (hmdC), 5‐formyl‐dC (fdC), and 5‐carboxy‐dC (cadC). Subsequent transformation of fdC and cadC back to dC by various pathways establishes a chemical intra‐genetic control circle. One of the discussed pathways involves the Tdg‐independent deformylation of fdC directly to dC. Here we report the synthesis of a fluorinated fdC feeding probe (F‐fdC) to study direct deformylation to F‐dC. The synthesis was performed along a novel pathway that circumvents any F‐dC as a reaction intermediate to avoid contamination interference. Feeding of F‐fdC and observation of F‐dC formation in vivo allowed us to gain insights into the Tdg‐independent removal process. While deformylation was shown to occur in stem cells, we here provide data that prove deformylation also in different somatic cell types. We also investigated active demethylation in a non‐dividing neurogenin‐inducible system of iPS cells that differentiate into bipolar neurons." @default.
- W3171363941 created "2021-06-22" @default.
- W3171363941 creator A5006191068 @default.
- W3171363941 creator A5024346205 @default.
- W3171363941 creator A5026032684 @default.
- W3171363941 creator A5063397487 @default.
- W3171363941 date "2021-06-24" @default.
- W3171363941 modified "2023-10-03" @default.
- W3171363941 title "Deformylation of 5‐Formylcytidine in Different Cell Types" @default.
- W3171363941 cites W1503311137 @default.
- W3171363941 cites W1505631367 @default.
- W3171363941 cites W1912177776 @default.
- W3171363941 cites W1984066495 @default.
- W3171363941 cites W1996676239 @default.
- W3171363941 cites W1997453048 @default.
- W3171363941 cites W2009573598 @default.
- W3171363941 cites W2020244243 @default.
- W3171363941 cites W2045885851 @default.
- W3171363941 cites W2046241907 @default.
- W3171363941 cites W2060446375 @default.
- W3171363941 cites W2075563645 @default.
- W3171363941 cites W2076255761 @default.
- W3171363941 cites W2093583739 @default.
- W3171363941 cites W2096391240 @default.
- W3171363941 cites W2101173364 @default.
- W3171363941 cites W2104687676 @default.
- W3171363941 cites W2132199053 @default.
- W3171363941 cites W2132493174 @default.
- W3171363941 cites W2156386262 @default.
- W3171363941 cites W2157458089 @default.
- W3171363941 cites W2161224111 @default.
- W3171363941 cites W2161326542 @default.
- W3171363941 cites W2508346302 @default.
- W3171363941 cites W2516479770 @default.
- W3171363941 cites W2517327266 @default.
- W3171363941 cites W2553149522 @default.
- W3171363941 cites W2735962445 @default.
- W3171363941 cites W2737414718 @default.
- W3171363941 cites W2768929279 @default.
- W3171363941 cites W2895991294 @default.
- W3171363941 cites W2905196328 @default.
- W3171363941 cites W2954804024 @default.
- W3171363941 cites W2973544117 @default.
- W3171363941 cites W3003629057 @default.
- W3171363941 cites W3008527316 @default.
- W3171363941 cites W3044653739 @default.
- W3171363941 cites W4249271197 @default.
- W3171363941 doi "https://doi.org/10.1002/anie.202107089" @default.
- W3171363941 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8362038" @default.
- W3171363941 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34110681" @default.
- W3171363941 hasPublicationYear "2021" @default.
- W3171363941 type Work @default.
- W3171363941 sameAs 3171363941 @default.
- W3171363941 citedByCount "5" @default.
- W3171363941 countsByYear W31713639412021 @default.
- W3171363941 countsByYear W31713639412022 @default.
- W3171363941 countsByYear W31713639412023 @default.
- W3171363941 crossrefType "journal-article" @default.
- W3171363941 hasAuthorship W3171363941A5006191068 @default.
- W3171363941 hasAuthorship W3171363941A5024346205 @default.
- W3171363941 hasAuthorship W3171363941A5026032684 @default.
- W3171363941 hasAuthorship W3171363941A5063397487 @default.
- W3171363941 hasBestOaLocation W31713639412 @default.
- W3171363941 hasConcept C104317684 @default.
- W3171363941 hasConcept C12554922 @default.
- W3171363941 hasConcept C150194340 @default.
- W3171363941 hasConcept C185592680 @default.
- W3171363941 hasConcept C190727270 @default.
- W3171363941 hasConcept C202199734 @default.
- W3171363941 hasConcept C33288867 @default.
- W3171363941 hasConcept C41091548 @default.
- W3171363941 hasConcept C552990157 @default.
- W3171363941 hasConcept C55493867 @default.
- W3171363941 hasConcept C86803240 @default.
- W3171363941 hasConceptScore W3171363941C104317684 @default.
- W3171363941 hasConceptScore W3171363941C12554922 @default.
- W3171363941 hasConceptScore W3171363941C150194340 @default.
- W3171363941 hasConceptScore W3171363941C185592680 @default.
- W3171363941 hasConceptScore W3171363941C190727270 @default.
- W3171363941 hasConceptScore W3171363941C202199734 @default.
- W3171363941 hasConceptScore W3171363941C33288867 @default.
- W3171363941 hasConceptScore W3171363941C41091548 @default.
- W3171363941 hasConceptScore W3171363941C552990157 @default.
- W3171363941 hasConceptScore W3171363941C55493867 @default.
- W3171363941 hasConceptScore W3171363941C86803240 @default.
- W3171363941 hasFunder F4320320879 @default.
- W3171363941 hasFunder F4320320882 @default.
- W3171363941 hasFunder F4320338335 @default.
- W3171363941 hasIssue "31" @default.
- W3171363941 hasLocation W31713639411 @default.
- W3171363941 hasLocation W31713639412 @default.
- W3171363941 hasOpenAccess W3171363941 @default.
- W3171363941 hasPrimaryLocation W31713639411 @default.
- W3171363941 hasRelatedWork W1455488868 @default.
- W3171363941 hasRelatedWork W1597747799 @default.
- W3171363941 hasRelatedWork W1999253883 @default.
- W3171363941 hasRelatedWork W2023083614 @default.
- W3171363941 hasRelatedWork W2048794814 @default.