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- W3171399821 abstract "Fructose (Frc) is metabolized differently from glucose, i.e., with initial metabolism by ketohexokinase (KHK), an enzyme associated with ATP depletion. To test whether a diet enriched in Frc might impair energy-intensive actions of the renal thick ascending limb (TAL), we evaluated TAL function and protein expression in response to 4-weeks of 10% Frc in drinking water in young (Y, 3 months) male (M) and female (F) and mid-aged F (A, 12 months) mice. Frc resulted in, on average, 11% lower kidney weights, regardless of age or sex. In addition, Frc caused a significant reduction in urine concentrating capacity, observed most dramatically in the aged females (F). Urine osmolality was (% of control): 95, 75, and 44 in YMFrc, YFFrc, and AFFrc, respectively. In contrast, Frc increased urine diluting capacity. However, this protective adaptation was attenuated in the AFFrc (urine osmolality % of C): 77 (YMFrc), 76 (YFFrc), 87 (AFFrc). Western blotting revealed 2–5X increased kidney cortex KHK expression in Frc groups, with the increase greatest in YFFrc. Frc resulted in a modest 20–60% increase in band density for the Na-K-2Cl cotransporter (NKCC2), the major apical sodium chloride cotransporter of the TAL, but only in Y mice. In the AFFrc it was reduced 30%. In summary, diets enriched in Frc may alter the ability of the TAL to effectively dilute and concentrate urine. Aging subjects may be especially vulnerable. NIH DK082507." @default.
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- W3171399821 date "2013-04-01" @default.
- W3171399821 modified "2023-09-27" @default.
- W3171399821 title "Altered thick ascending limb function in aging female mice consuming high quantities of fructose‐sweetened water" @default.
- W3171399821 doi "https://doi.org/10.1096/fasebj.27.1_supplement.1115.13" @default.
- W3171399821 hasPublicationYear "2013" @default.
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