FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3171415090> ?p ?o ?g. }

• W3171415090 endingPage "1315" @default.
• W3171415090 startingPage "1315" @default.
• W3171415090 abstract "1315 Objectives: The use of quantitative imaging biomarkers are becoming a promising technique to allow tumor load quantification. For 18F-FDG-PET/CT, such concepts already exist, for example, the whole-body tumor burden has been shown to correlate directly with tumor aggressiveness of several tumors. The concept of whole-body tumor burden in patients with prostate cancer has only been assessed with 68Ga-PSMA PET/CT. Recently the development of 18F labeled PSMA compounds, has been shown to offer higher detection rates in biochemically recurrent prostate cancer after primary therapy. Therefore, we aim to evaluate if 18F-PSMA-1007 ligand PET/CT may provide PSMA-derived volumetric parameters for quantification of whole-body tumor burden. Methods: This retrospective study evaluated 101 patients referred for 18F-PSMA-1007 PET/CT with biochemical recurrence or PSA persistence after radical prostatectomy. The PSMA whole-body tumor burden metrics on 18F-PSMA-1007 were obtained semiautomatically in a dedicated software, all uptakes not related to metastatic sites were excluded. The software automatically generated the total tumor volume (PSMA-TV) and the total PSMA uptake in lesions (PSMA-TL). Descriptive statistics are absolute and relative frequencies, mean, median, standard deviation, and range were used to characterize the study population. Spearman correlation was used to explore the association of imaging findings with PSA levels. A subgroup analysis was performed dividing the data into three groups, depending on their Gleason scores <6, 7 -8, and 9-10, statistical significance was established for P values of 0.05 or less. Results: Among the 101 PSMA PET studies, a total of 501 metastatic lesions were analyzed, a significant correlation was observed with wbPSMA-TV (r=0.533, P<0.0001) and wbPSMA-TL (r= 0.654, P<0.0001). In the subgroup analysis, there was a significant correlation in the three Gleason groups. However, wbTL-PSMA and PSA were strongly correlated especially in the group of patients with Gleason score <6 (r=0.78, p=0.0001, 95% CI 0.60-90). Conclusions: The results of our study show that 18F-PSMA-1007 volumetric parameters demonstrate a highly significant correlation with serum-PSA levels, especially wbPSMA-TL. The use of volumetric parameters could be a potential imaging biomarker for whole-body tumor assessment, capable of standardizing quantitative changes in PET imaging in patients with biochemically recurrent prostate cancer.Acknowledgments: We acknowledge the contributions of all team members from the PET/CT Unit from the National Autonomous University of Mexico." @default.
• W3171415090 created "2021-06-22" @default.
• W3171415090 creator A5032673244 @default.
• W3171415090 creator A5067530151 @default.
• W3171415090 creator A5075055692 @default.
• W3171415090 date "2021-05-01" @default.
• W3171415090 modified "2023-09-30" @default.
• W3171415090 title "Initial experience with volumetric 18F-PSMA-1007 PET/CT for assessment of whole-body tumor burden as a quantitative imaging biomarker in biochemically recurrent prostate cancer" @default.
• W3171415090 hasPublicationYear "2021" @default.
• W3171415090 type Work @default.
• W3171415090 sameAs 3171415090 @default.
• W3171415090 citedByCount "0" @default.
• W3171415090 crossrefType "journal-article" @default.
• W3171415090 hasAuthorship W3171415090A5032673244 @default.
• W3171415090 hasAuthorship W3171415090A5067530151 @default.
• W3171415090 hasAuthorship W3171415090A5075055692 @default.
• W3171415090 hasConcept C121608353 @default.
• W3171415090 hasConcept C126322002 @default.
• W3171415090 hasConcept C126838900 @default.
• W3171415090 hasConcept C143409427 @default.
• W3171415090 hasConcept C143998085 @default.
• W3171415090 hasConcept C185592680 @default.
• W3171415090 hasConcept C2775842073 @default.
• W3171415090 hasConcept C2776235491 @default.
• W3171415090 hasConcept C2776410896 @default.
• W3171415090 hasConcept C2777008409 @default.
• W3171415090 hasConcept C2779013556 @default.
• W3171415090 hasConcept C2779466945 @default.
• W3171415090 hasConcept C2780192828 @default.
• W3171415090 hasConcept C2780283643 @default.
• W3171415090 hasConcept C2781197716 @default.
• W3171415090 hasConcept C2908647359 @default.
• W3171415090 hasConcept C2989005 @default.
• W3171415090 hasConcept C45664433 @default.
• W3171415090 hasConcept C55493867 @default.
• W3171415090 hasConcept C71924100 @default.
• W3171415090 hasConcept C99454951 @default.
• W3171415090 hasConceptScore W3171415090C121608353 @default.
• W3171415090 hasConceptScore W3171415090C126322002 @default.
• W3171415090 hasConceptScore W3171415090C126838900 @default.
• W3171415090 hasConceptScore W3171415090C143409427 @default.
• W3171415090 hasConceptScore W3171415090C143998085 @default.
• W3171415090 hasConceptScore W3171415090C185592680 @default.
• W3171415090 hasConceptScore W3171415090C2775842073 @default.
• W3171415090 hasConceptScore W3171415090C2776235491 @default.
• W3171415090 hasConceptScore W3171415090C2776410896 @default.
• W3171415090 hasConceptScore W3171415090C2777008409 @default.
• W3171415090 hasConceptScore W3171415090C2779013556 @default.
• W3171415090 hasConceptScore W3171415090C2779466945 @default.
• W3171415090 hasConceptScore W3171415090C2780192828 @default.
• W3171415090 hasConceptScore W3171415090C2780283643 @default.
• W3171415090 hasConceptScore W3171415090C2781197716 @default.
• W3171415090 hasConceptScore W3171415090C2908647359 @default.
• W3171415090 hasConceptScore W3171415090C2989005 @default.
• W3171415090 hasConceptScore W3171415090C45664433 @default.
• W3171415090 hasConceptScore W3171415090C55493867 @default.
• W3171415090 hasConceptScore W3171415090C71924100 @default.
• W3171415090 hasConceptScore W3171415090C99454951 @default.
• W3171415090 hasLocation W31714150901 @default.
• W3171415090 hasOpenAccess W3171415090 @default.
• W3171415090 hasPrimaryLocation W31714150901 @default.
• W3171415090 hasRelatedWork W2754546503 @default.
• W3171415090 hasRelatedWork W2883850634 @default.
• W3171415090 hasRelatedWork W2888932351 @default.
• W3171415090 hasRelatedWork W2914633376 @default.
• W3171415090 hasRelatedWork W2945522704 @default.
• W3171415090 hasRelatedWork W2949625509 @default.
• W3171415090 hasRelatedWork W3026141276 @default.
• W3171415090 hasRelatedWork W3033157114 @default.
• W3171415090 hasRelatedWork W3046625835 @default.
• W3171415090 hasRelatedWork W3049219909 @default.
• W3171415090 hasRelatedWork W3087009286 @default.
• W3171415090 hasRelatedWork W3088497176 @default.
• W3171415090 hasRelatedWork W3131753125 @default.
• W3171415090 hasRelatedWork W3145933933 @default.
• W3171415090 hasRelatedWork W3152760736 @default.
• W3171415090 hasRelatedWork W3170886129 @default.
• W3171415090 hasRelatedWork W3173989317 @default.
• W3171415090 hasRelatedWork W3183807799 @default.
• W3171415090 hasRelatedWork W3209889299 @default.
• W3171415090 hasRelatedWork W3210344432 @default.
• W3171415090 hasVolume "62" @default.
• W3171415090 isParatext "false" @default.
• W3171415090 isRetracted "false" @default.
• W3171415090 magId "3171415090" @default.
• W3171415090 workType "article" @default.