Matches in SemOpenAlex for { <https://semopenalex.org/work/W3171446174> ?p ?o ?g. }
- W3171446174 endingPage "198471" @default.
- W3171446174 startingPage "198471" @default.
- W3171446174 abstract "Bovine viral diarrhea virus (BVDV) is an important member of the family Flaviviridae and often causes immunosuppression. Previous studies have suggested that BVDV envelope protein Erns and the nonstructural autoprotease Npro can inhibit host innate immune responses. Herein, we found that BVDV NS4B, as a nonstructural protein necessary for replication, is involved in antagonizing the main RNA virus sensing pathway. Overexpression of BVDV NS4B protein significantly inhibited Sendai virus (SeV)-induced interferon-β promoter activity, IFN-β mRNA and IFN regulatory factor 3 (IRF3) phosphorylation levels. We also discovered that BVDV NS4B protein significantly inhibited RIG-I like receptor (RLRs)-mediated interferon-β (IFN-β) promoter activity and endogenous MDA5 mRNA levels. In addition, the BVDV NS4B protein directly interacts with N-terminal CARDs of MDA5, and co-localized with MDA5 or MDA5-2CARD in the cytoplasm. In summary, the results of this study indicate that the BVDV NS4B protein acts as an interferon-β antagonist through inhibiting the MDA5-mediated signal transduction pathway. Our study provides an in-depth understanding of the molecular mechanisms of BVDV evading the host's natural immune response." @default.
- W3171446174 created "2021-06-22" @default.
- W3171446174 creator A5004487040 @default.
- W3171446174 creator A5004984009 @default.
- W3171446174 creator A5017816917 @default.
- W3171446174 creator A5017901151 @default.
- W3171446174 creator A5019823705 @default.
- W3171446174 creator A5021647613 @default.
- W3171446174 creator A5035105876 @default.
- W3171446174 creator A5040290579 @default.
- W3171446174 creator A5041661052 @default.
- W3171446174 creator A5043266919 @default.
- W3171446174 creator A5045462660 @default.
- W3171446174 creator A5052769403 @default.
- W3171446174 creator A5068383527 @default.
- W3171446174 creator A5072441748 @default.
- W3171446174 creator A5084174028 @default.
- W3171446174 creator A5085494676 @default.
- W3171446174 date "2021-09-01" @default.
- W3171446174 modified "2023-10-17" @default.
- W3171446174 title "Bovine viral diarrhea virus NS4B protein interacts with 2CARD of MDA5 domain and negatively regulates the RLR-mediated IFN-β production" @default.
- W3171446174 cites W1224128220 @default.
- W3171446174 cites W1973646620 @default.
- W3171446174 cites W1983921697 @default.
- W3171446174 cites W2004837009 @default.
- W3171446174 cites W2010091770 @default.
- W3171446174 cites W2035494209 @default.
- W3171446174 cites W2046886534 @default.
- W3171446174 cites W2051206691 @default.
- W3171446174 cites W2066728093 @default.
- W3171446174 cites W2078708664 @default.
- W3171446174 cites W2124651203 @default.
- W3171446174 cites W2149265260 @default.
- W3171446174 cites W2155518363 @default.
- W3171446174 cites W2157167271 @default.
- W3171446174 cites W2159685069 @default.
- W3171446174 cites W2179871497 @default.
- W3171446174 cites W2279656743 @default.
- W3171446174 cites W2284625703 @default.
- W3171446174 cites W2341421367 @default.
- W3171446174 cites W2605720164 @default.
- W3171446174 cites W2607173880 @default.
- W3171446174 cites W2728296348 @default.
- W3171446174 cites W2763801778 @default.
- W3171446174 cites W2774114235 @default.
- W3171446174 cites W2804363037 @default.
- W3171446174 cites W2889456200 @default.
- W3171446174 cites W2894202995 @default.
- W3171446174 cites W2897501065 @default.
- W3171446174 cites W2903838789 @default.
- W3171446174 cites W2917772670 @default.
- W3171446174 cites W2918681749 @default.
- W3171446174 cites W2982703661 @default.
- W3171446174 cites W3033123969 @default.
- W3171446174 cites W3046271622 @default.
- W3171446174 cites W3111065404 @default.
- W3171446174 cites W3126351555 @default.
- W3171446174 doi "https://doi.org/10.1016/j.virusres.2021.198471" @default.
- W3171446174 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34097933" @default.
- W3171446174 hasPublicationYear "2021" @default.
- W3171446174 type Work @default.
- W3171446174 sameAs 3171446174 @default.
- W3171446174 citedByCount "10" @default.
- W3171446174 countsByYear W31714461742021 @default.
- W3171446174 countsByYear W31714461742022 @default.
- W3171446174 countsByYear W31714461742023 @default.
- W3171446174 crossrefType "journal-article" @default.
- W3171446174 hasAuthorship W3171446174A5004487040 @default.
- W3171446174 hasAuthorship W3171446174A5004984009 @default.
- W3171446174 hasAuthorship W3171446174A5017816917 @default.
- W3171446174 hasAuthorship W3171446174A5017901151 @default.
- W3171446174 hasAuthorship W3171446174A5019823705 @default.
- W3171446174 hasAuthorship W3171446174A5021647613 @default.
- W3171446174 hasAuthorship W3171446174A5035105876 @default.
- W3171446174 hasAuthorship W3171446174A5040290579 @default.
- W3171446174 hasAuthorship W3171446174A5041661052 @default.
- W3171446174 hasAuthorship W3171446174A5043266919 @default.
- W3171446174 hasAuthorship W3171446174A5045462660 @default.
- W3171446174 hasAuthorship W3171446174A5052769403 @default.
- W3171446174 hasAuthorship W3171446174A5068383527 @default.
- W3171446174 hasAuthorship W3171446174A5072441748 @default.
- W3171446174 hasAuthorship W3171446174A5084174028 @default.
- W3171446174 hasAuthorship W3171446174A5085494676 @default.
- W3171446174 hasConcept C104317684 @default.
- W3171446174 hasConcept C134474686 @default.
- W3171446174 hasConcept C136449434 @default.
- W3171446174 hasConcept C140704245 @default.
- W3171446174 hasConcept C159047783 @default.
- W3171446174 hasConcept C161238802 @default.
- W3171446174 hasConcept C166703698 @default.
- W3171446174 hasConcept C195794163 @default.
- W3171446174 hasConcept C203014093 @default.
- W3171446174 hasConcept C2522874641 @default.
- W3171446174 hasConcept C2776178377 @default.
- W3171446174 hasConcept C2780127873 @default.
- W3171446174 hasConcept C2780209191 @default.
- W3171446174 hasConcept C55493867 @default.
- W3171446174 hasConcept C62478195 @default.