Matches in SemOpenAlex for { <https://semopenalex.org/work/W3171461337> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W3171461337 abstract "Renal ischemia-reperfusion injury (IRI) is a complex disorder characterized by varying degrees of structural and functional losses. The degree of the insult depends on the severity of the condition and the kidney's ability to recover. IRI simultaneously contributes to the development of acute tubular injury and microvascular/endothelial injury. To further complicate matters, it is also believed that microvascular/endothelial injury leads to apoptotic signaling to, in turn, further reduce capillary density and blood flow, and exacerbate tubular damage that supports the transition from acute to chronic disorders. In recent times, studies have employed intravital imaging systems to enhance our understanding of these mechanisms. Such studies have identified ways that intravital renal imaging can be used to track apoptosis in vivo. As a result, we aimed to build on this convention by searching for evidence of apoptotic signaling at the onset of IRI. Using intravital two-photon microscopy, fluorescent micrographs of tubular nuclei were collected and examined at the onset of ischemia. Signs of apoptosis were identified by cell shrinkage that led to the formation of apoptotic bodies. Furthermore, the concurrent presence of necrotic signaling, which led to increased cell permeability and swelling, was also visualized. Altogether these results confirm the presence of apoptotic signaling, as well as, necrotic signaling, and provide important evidence about the previously unconfirmed cell death mechanisms that can support the debilitating progression of IRI." @default.
- W3171461337 created "2021-06-22" @default.
- W3171461337 creator A5007571113 @default.
- W3171461337 creator A5031914841 @default.
- W3171461337 creator A5056230134 @default.
- W3171461337 creator A5077531609 @default.
- W3171461337 creator A5088041867 @default.
- W3171461337 date "2021-05-01" @default.
- W3171461337 modified "2023-10-14" @default.
- W3171461337 title "Real‐time in vivo imaging confirms the presence of apoptotic signaling at the onset of ischemia‐reperfusion injury" @default.
- W3171461337 doi "https://doi.org/10.1096/fasebj.2021.35.s1.00320" @default.
- W3171461337 hasPublicationYear "2021" @default.
- W3171461337 type Work @default.
- W3171461337 sameAs 3171461337 @default.
- W3171461337 citedByCount "0" @default.
- W3171461337 crossrefType "journal-article" @default.
- W3171461337 hasAuthorship W3171461337A5007571113 @default.
- W3171461337 hasAuthorship W3171461337A5031914841 @default.
- W3171461337 hasAuthorship W3171461337A5056230134 @default.
- W3171461337 hasAuthorship W3171461337A5077531609 @default.
- W3171461337 hasAuthorship W3171461337A5088041867 @default.
- W3171461337 hasConcept C113045295 @default.
- W3171461337 hasConcept C123012128 @default.
- W3171461337 hasConcept C126322002 @default.
- W3171461337 hasConcept C12722491 @default.
- W3171461337 hasConcept C142724271 @default.
- W3171461337 hasConcept C150903083 @default.
- W3171461337 hasConcept C190283241 @default.
- W3171461337 hasConcept C202751555 @default.
- W3171461337 hasConcept C207001950 @default.
- W3171461337 hasConcept C2780114680 @default.
- W3171461337 hasConcept C2859252 @default.
- W3171461337 hasConcept C31573885 @default.
- W3171461337 hasConcept C541997718 @default.
- W3171461337 hasConcept C55493867 @default.
- W3171461337 hasConcept C62478195 @default.
- W3171461337 hasConcept C71924100 @default.
- W3171461337 hasConcept C86803240 @default.
- W3171461337 hasConcept C95444343 @default.
- W3171461337 hasConceptScore W3171461337C113045295 @default.
- W3171461337 hasConceptScore W3171461337C123012128 @default.
- W3171461337 hasConceptScore W3171461337C126322002 @default.
- W3171461337 hasConceptScore W3171461337C12722491 @default.
- W3171461337 hasConceptScore W3171461337C142724271 @default.
- W3171461337 hasConceptScore W3171461337C150903083 @default.
- W3171461337 hasConceptScore W3171461337C190283241 @default.
- W3171461337 hasConceptScore W3171461337C202751555 @default.
- W3171461337 hasConceptScore W3171461337C207001950 @default.
- W3171461337 hasConceptScore W3171461337C2780114680 @default.
- W3171461337 hasConceptScore W3171461337C2859252 @default.
- W3171461337 hasConceptScore W3171461337C31573885 @default.
- W3171461337 hasConceptScore W3171461337C541997718 @default.
- W3171461337 hasConceptScore W3171461337C55493867 @default.
- W3171461337 hasConceptScore W3171461337C62478195 @default.
- W3171461337 hasConceptScore W3171461337C71924100 @default.
- W3171461337 hasConceptScore W3171461337C86803240 @default.
- W3171461337 hasConceptScore W3171461337C95444343 @default.
- W3171461337 hasIssue "S1" @default.
- W3171461337 hasLocation W31714613371 @default.
- W3171461337 hasOpenAccess W3171461337 @default.
- W3171461337 hasPrimaryLocation W31714613371 @default.
- W3171461337 hasRelatedWork W1930828223 @default.
- W3171461337 hasRelatedWork W1991435357 @default.
- W3171461337 hasRelatedWork W2003630344 @default.
- W3171461337 hasRelatedWork W2018299428 @default.
- W3171461337 hasRelatedWork W2018762413 @default.
- W3171461337 hasRelatedWork W2039567390 @default.
- W3171461337 hasRelatedWork W2041433855 @default.
- W3171461337 hasRelatedWork W2048624283 @default.
- W3171461337 hasRelatedWork W2049269243 @default.
- W3171461337 hasRelatedWork W2116134279 @default.
- W3171461337 hasVolume "35" @default.
- W3171461337 isParatext "false" @default.
- W3171461337 isRetracted "false" @default.
- W3171461337 magId "3171461337" @default.
- W3171461337 workType "article" @default.