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- W3171474328 abstract "Age-related macular degeneration (AMD) is one of the most common causes of severe visual loss in middle and old-age population, and often leads to serious deterioration in quality of life. Currently, the first-line treatment for neovascular AMD (nAMD) are intravitreal injections of anti-vascular endothelial growth factor (VEGF) medications, including bevacizumab, ranibizumab, and aflibercept and also latest commercially available drug, brolucizumab. During initial examination and imaging and treatment follow-up for patients with nAMD, optical coherence tomography (OCT) is used to predict and assess the therapeutic response and guide the treatment. Several OCT-based biomarkers, including the central subfoveal thickness (CSFT), the presence of intraretinal cysts (IRCs) or subretinal fluid (SRF), and the presence of pigment epithelial detachment (PED), were found to influence baseline visual acuity or visual improvements. Recent analyses of large randomized control trials (RCTs) summarized the usefulness of these OCT-based biomarkers. However, many of these early studies relied on time-domain OCT to evaluate the retinal structures thus providing less precise evaluation of the retinal details. After introduction of spectral-domain OCT (SD-OCT) which provided high resolution images, recent studies offered new insights in specific morphological changes and their different impact on visual function in nAMD. For example, these advancement in resolution offered new classification of IRCs into degenerative and exudative which impacts treatment strategy and final outcome in the treatment of nAMD. Moreover, the recent data disclose a substantial difference between RCTs and real-world studies regarding the response to anti-VEGF therapy. In conclusions, IRCs and PED are associated with poor visual improvement in nAMD in a realworld setting. Both IRCs and SRF responded better than PED to anti-VEGF therapy. These observations mandate large longitudinal studies focusing on the usefulness of these high resolution SD-OCT biomarkers in real-world situations." @default.
- W3171474328 created "2021-06-22" @default.
- W3171474328 creator A5018771948 @default.
- W3171474328 creator A5022641686 @default.
- W3171474328 creator A5073092963 @default.
- W3171474328 date "2022-09-28" @default.
- W3171474328 modified "2023-09-26" @default.
- W3171474328 title "Anti-VEGF Treatment and Optical Coherence Tomography Biomarkers in Wet Age-Related Macular Degeneration" @default.
- W3171474328 cites W1458919156 @default.
- W3171474328 cites W1802218256 @default.
- W3171474328 cites W1965083039 @default.
- W3171474328 cites W1968691111 @default.
- W3171474328 cites W1970699493 @default.
- W3171474328 cites W1972642682 @default.
- W3171474328 cites W1983443598 @default.
- W3171474328 cites W1990889412 @default.
- W3171474328 cites W1998386860 @default.
- W3171474328 cites W2004117352 @default.
- W3171474328 cites W2007014682 @default.
- W3171474328 cites W2010869820 @default.
- W3171474328 cites W2018396038 @default.
- W3171474328 cites W2020761135 @default.
- W3171474328 cites W2063028754 @default.
- W3171474328 cites W2063967273 @default.
- W3171474328 cites W2085712747 @default.
- W3171474328 cites W2093646832 @default.
- W3171474328 cites W2116942242 @default.
- W3171474328 cites W2119635054 @default.
- W3171474328 cites W2124415048 @default.
- W3171474328 cites W2125587232 @default.
- W3171474328 cites W2128943765 @default.
- W3171474328 cites W2135936686 @default.
- W3171474328 cites W2136940845 @default.
- W3171474328 cites W2138787512 @default.
- W3171474328 cites W2138903426 @default.
- W3171474328 cites W2143760058 @default.
- W3171474328 cites W2151876190 @default.
- W3171474328 cites W2159028507 @default.
- W3171474328 cites W2160226180 @default.
- W3171474328 cites W2160726762 @default.
- W3171474328 cites W2172453889 @default.
- W3171474328 cites W2195866396 @default.
- W3171474328 cites W2207811656 @default.
- W3171474328 cites W2225799082 @default.
- W3171474328 cites W2233418582 @default.
- W3171474328 cites W2264321694 @default.
- W3171474328 cites W2304396421 @default.
- W3171474328 cites W2313014471 @default.
- W3171474328 cites W2317136217 @default.
- W3171474328 cites W2333968513 @default.
- W3171474328 cites W2343042175 @default.
- W3171474328 cites W2346873848 @default.
- W3171474328 cites W2467637665 @default.
- W3171474328 cites W2524064376 @default.
- W3171474328 cites W2530346751 @default.
- W3171474328 cites W2545082692 @default.
- W3171474328 cites W2556011637 @default.
- W3171474328 cites W2557377979 @default.
- W3171474328 cites W2566756969 @default.
- W3171474328 cites W2601742736 @default.
- W3171474328 cites W2602444060 @default.
- W3171474328 cites W2604064275 @default.
- W3171474328 cites W2616502721 @default.
- W3171474328 cites W2740062018 @default.
- W3171474328 cites W2767736688 @default.
- W3171474328 cites W2768390170 @default.
- W3171474328 cites W2777721386 @default.
- W3171474328 cites W2786459496 @default.
- W3171474328 cites W2790319105 @default.
- W3171474328 cites W2792402771 @default.
- W3171474328 cites W2800341854 @default.
- W3171474328 cites W2800420264 @default.
- W3171474328 cites W2809119771 @default.
- W3171474328 cites W2887429619 @default.
- W3171474328 cites W2888207742 @default.
- W3171474328 cites W2888741588 @default.
- W3171474328 cites W2889498071 @default.
- W3171474328 cites W2889991336 @default.
- W3171474328 cites W2899005383 @default.
- W3171474328 cites W2899062196 @default.
- W3171474328 cites W2901004898 @default.
- W3171474328 cites W2905164438 @default.
- W3171474328 cites W290847105 @default.
- W3171474328 cites W2911382880 @default.
- W3171474328 cites W2936430874 @default.
- W3171474328 cites W2948088537 @default.
- W3171474328 cites W2950157209 @default.
- W3171474328 cites W2958378567 @default.
- W3171474328 cites W2964546533 @default.
- W3171474328 cites W2981945682 @default.
- W3171474328 cites W2994967969 @default.
- W3171474328 cites W3005852648 @default.
- W3171474328 cites W3015121411 @default.
- W3171474328 cites W3016627210 @default.
- W3171474328 cites W3025037911 @default.
- W3171474328 cites W3046958134 @default.
- W3171474328 cites W3063189849 @default.
- W3171474328 cites W4211020962 @default.
- W3171474328 doi "https://doi.org/10.5772/intechopen.97689" @default.
- W3171474328 hasPublicationYear "2022" @default.