FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3171497227> ?p ?o ?g. }

• W3171497227 abstract "According to an estimate from the American Cancer Society in 2018, 1,735,350 people were expected to be diagnosed with cancer in the United States, with 609,640 dying from the disease. The late diagnosis of cancer has a negative impact on the health care system due to higher treatment cost and decreased chances of favorable prognosis. Due to the nature of their profession, dentists and their teams are well positioned to identify oral risk markers related to cancer, which increases the potential for early diagnosis and chances of survival. For example, tooth agenesis has been associated with increased risk for ovarian cancer. A greater awareness of oral conditions that are linked to genetic predictors of cancer susceptibility will provide dentists an opportunity to improve patient outcomes by suggesting genetic screenings for prevention. The objective of this study is to identify craniofacial conditions that might be risk markers for cancers by performing association studies and approaches such as a phenome-wide association study (PheWAS) including orofacial phenotypes. A PheWAS can determine if clinical traits (phenotypes) or specific diagnosis are associated with a given genetic variant. Hence, this study will evaluate if selected single nucleotide polymorphisms (SNPs) present in cell regulatory gene pathways are associated with orofacial conditions affecting the study population; determine whether there is an increased frequency of these conditions among individuals who have been diagnosed with cancer compared to healthy controls; and identify the range of head and neck conditions associated with the selected SNPs through a PheWAS approach. All samples were obtained through the Dental Registry and DNA Repository (DRDR) at the University of Pittsburgh, School of Dental Medicine. DNA was extracted from whole saliva using established protocols and genotyping data from over 3,000 individuals were generated using TaqMan chemistry. PLINK software was used to perform allele frequency tests and a logistic regression using R environment was performed taking covariates such as ethnicity and gender into account. We found several genetic associations with the phenotypes of interest that were later confirmed with the PheWAS approach. Additionally, novel associations that can potentially be markers of cancer risk were found." @default.
• W3171497227 created "2021-06-22" @default.
• W3171497227 creator A5070346634 @default.
• W3171497227 date "2021-06-03" @default.
• W3171497227 modified "2023-09-23" @default.
• W3171497227 title "ORAL HEALTH OUTCOMES AS POTENTIAL INDICATORS OF CANCER EXPERIENCE" @default.
• W3171497227 cites W1512005401 @default.
• W3171497227 cites W1862838614 @default.
• W3171497227 cites W1916751165 @default.
• W3171497227 cites W1961416276 @default.
• W3171497227 cites W1965536389 @default.
• W3171497227 cites W1970090817 @default.
• W3171497227 cites W1972586136 @default.
• W3171497227 cites W1983519619 @default.
• W3171497227 cites W1983896684 @default.
• W3171497227 cites W1996557314 @default.
• W3171497227 cites W1997426926 @default.
• W3171497227 cites W2000042026 @default.
• W3171497227 cites W2033106726 @default.
• W3171497227 cites W2041177943 @default.
• W3171497227 cites W2048906289 @default.
• W3171497227 cites W2049159646 @default.
• W3171497227 cites W2054077079 @default.
• W3171497227 cites W2054912161 @default.
• W3171497227 cites W2057106513 @default.
• W3171497227 cites W2062997257 @default.
• W3171497227 cites W2067131562 @default.
• W3171497227 cites W2083678740 @default.
• W3171497227 cites W2089198803 @default.
• W3171497227 cites W2093274439 @default.
• W3171497227 cites W2099963615 @default.
• W3171497227 cites W2102215872 @default.
• W3171497227 cites W2113105800 @default.
• W3171497227 cites W2113129492 @default.
• W3171497227 cites W2125550499 @default.
• W3171497227 cites W2126693515 @default.
• W3171497227 cites W2129009186 @default.
• W3171497227 cites W2130698371 @default.
• W3171497227 cites W2144528549 @default.
• W3171497227 cites W2157116817 @default.
• W3171497227 cites W2157974577 @default.
• W3171497227 cites W2159552267 @default.
• W3171497227 cites W2161083011 @default.
• W3171497227 cites W2161633633 @default.
• W3171497227 cites W2162017248 @default.
• W3171497227 cites W2164199515 @default.
• W3171497227 cites W2166505025 @default.
• W3171497227 cites W2168552231 @default.
• W3171497227 cites W2254153826 @default.
• W3171497227 cites W2296064435 @default.
• W3171497227 cites W2357845632 @default.
• W3171497227 cites W2403427843 @default.
• W3171497227 cites W2508835857 @default.
• W3171497227 cites W2536687083 @default.
• W3171497227 cites W2576646150 @default.
• W3171497227 cites W2593228368 @default.
• W3171497227 cites W2604728120 @default.
• W3171497227 cites W2758690751 @default.
• W3171497227 cites W2765242536 @default.
• W3171497227 cites W2765475577 @default.
• W3171497227 cites W2782754794 @default.
• W3171497227 cites W2789055329 @default.
• W3171497227 cites W2804896201 @default.
• W3171497227 cites W2811050895 @default.
• W3171497227 cites W2843762992 @default.
• W3171497227 cites W2890460936 @default.
• W3171497227 cites W2896395002 @default.
• W3171497227 cites W2954917865 @default.
• W3171497227 cites W2999630974 @default.
• W3171497227 hasPublicationYear "2021" @default.
• W3171497227 type Work @default.
• W3171497227 sameAs 3171497227 @default.
• W3171497227 citedByCount "0" @default.
• W3171497227 crossrefType "journal-article" @default.
• W3171497227 hasAuthorship W3171497227A5070346634 @default.
• W3171497227 hasConcept C104317684 @default.
• W3171497227 hasConcept C121608353 @default.
• W3171497227 hasConcept C126322002 @default.
• W3171497227 hasConcept C127716648 @default.
• W3171497227 hasConcept C135763542 @default.
• W3171497227 hasConcept C153209595 @default.
• W3171497227 hasConcept C2776530083 @default.
• W3171497227 hasConcept C2779134260 @default.
• W3171497227 hasConcept C2908647359 @default.
• W3171497227 hasConcept C54355233 @default.
• W3171497227 hasConcept C60644358 @default.
• W3171497227 hasConcept C71924100 @default.
• W3171497227 hasConcept C7952369 @default.
• W3171497227 hasConcept C86803240 @default.
• W3171497227 hasConcept C99454951 @default.
• W3171497227 hasConceptScore W3171497227C104317684 @default.
• W3171497227 hasConceptScore W3171497227C121608353 @default.
• W3171497227 hasConceptScore W3171497227C126322002 @default.
• W3171497227 hasConceptScore W3171497227C127716648 @default.
• W3171497227 hasConceptScore W3171497227C135763542 @default.
• W3171497227 hasConceptScore W3171497227C153209595 @default.
• W3171497227 hasConceptScore W3171497227C2776530083 @default.
• W3171497227 hasConceptScore W3171497227C2779134260 @default.
• W3171497227 hasConceptScore W3171497227C2908647359 @default.
• W3171497227 hasConceptScore W3171497227C54355233 @default.

• next