Matches in SemOpenAlex for { <https://semopenalex.org/work/W3171582227> ?p ?o ?g. }
Showing items 1 to 66 of
66
with 100 items per page.
- W3171582227 abstract "Several clinical trials are investigating the use of immune-targeted therapy with Programmed death ligand-1 (PD-L1) inhibitors for colorectal cancer (CRC), with promising results for patients with mismatch repair (MMR) deficiency or metastatic CRC. However, the prognostic significance of PD-L1 expression in CRC is controversial and such data is lacking in CRC from Middle Eastern ethnicity. We carried out this large retrospective study to investigate the prognostic and clinico-pathological impact of PD-L1 expression in 1148 Middle Eastern CRC using immunohistochemistry. High PD-L1 expression was noted in 37.3% (428/1148) cases and correlated with aggressive clinico-pathological features such as high-grade (p < 0.0001), larger tumor size (p = 0.0007) and mucinous histology (p = 0.0005). Interestingly, PD-L1 expression was significantly higher in patients exhibiting MMR deficiency (p = 0.0169) and BRAF mutation (p = 0.0008). Furthermore, the expression of PD-L1 was found to be an independent marker for overall survival (HR=1.45; 95% CI=1.06–1.99; p=0.0200). In conclusion, the results of this study indicate that PD-L1 expression could be a valid biomarker for poor prognosis in Middle Eastern CRC patients. This information can help in decision-making for anti-PD-L1 therapy in Middle Eastern CRC, especially for patients with MMR deficient tumors." @default.
- W3171582227 created "2021-06-22" @default.
- W3171582227 creator A5018975121 @default.
- W3171582227 creator A5031293775 @default.
- W3171582227 creator A5046517475 @default.
- W3171582227 creator A5047305971 @default.
- W3171582227 creator A5075156691 @default.
- W3171582227 creator A5080642590 @default.
- W3171582227 date "2021-05-01" @default.
- W3171582227 modified "2023-09-27" @default.
- W3171582227 title "PD‐L1 Expression is Associated with Deficient Mismatch Repair and Poor Prognosis in Middle Eastern Colorectal Cancers" @default.
- W3171582227 doi "https://doi.org/10.1096/fasebj.2021.35.s1.03426" @default.
- W3171582227 hasPublicationYear "2021" @default.
- W3171582227 type Work @default.
- W3171582227 sameAs 3171582227 @default.
- W3171582227 citedByCount "0" @default.
- W3171582227 crossrefType "journal-article" @default.
- W3171582227 hasAuthorship W3171582227A5018975121 @default.
- W3171582227 hasAuthorship W3171582227A5031293775 @default.
- W3171582227 hasAuthorship W3171582227A5046517475 @default.
- W3171582227 hasAuthorship W3171582227A5047305971 @default.
- W3171582227 hasAuthorship W3171582227A5075156691 @default.
- W3171582227 hasAuthorship W3171582227A5080642590 @default.
- W3171582227 hasConcept C121608353 @default.
- W3171582227 hasConcept C126322002 @default.
- W3171582227 hasConcept C143998085 @default.
- W3171582227 hasConcept C204232928 @default.
- W3171582227 hasConcept C207886595 @default.
- W3171582227 hasConcept C2781197716 @default.
- W3171582227 hasConcept C526805850 @default.
- W3171582227 hasConcept C55493867 @default.
- W3171582227 hasConcept C57742111 @default.
- W3171582227 hasConcept C60748783 @default.
- W3171582227 hasConcept C71924100 @default.
- W3171582227 hasConcept C86803240 @default.
- W3171582227 hasConceptScore W3171582227C121608353 @default.
- W3171582227 hasConceptScore W3171582227C126322002 @default.
- W3171582227 hasConceptScore W3171582227C143998085 @default.
- W3171582227 hasConceptScore W3171582227C204232928 @default.
- W3171582227 hasConceptScore W3171582227C207886595 @default.
- W3171582227 hasConceptScore W3171582227C2781197716 @default.
- W3171582227 hasConceptScore W3171582227C526805850 @default.
- W3171582227 hasConceptScore W3171582227C55493867 @default.
- W3171582227 hasConceptScore W3171582227C57742111 @default.
- W3171582227 hasConceptScore W3171582227C60748783 @default.
- W3171582227 hasConceptScore W3171582227C71924100 @default.
- W3171582227 hasConceptScore W3171582227C86803240 @default.
- W3171582227 hasIssue "S1" @default.
- W3171582227 hasLocation W31715822271 @default.
- W3171582227 hasOpenAccess W3171582227 @default.
- W3171582227 hasPrimaryLocation W31715822271 @default.
- W3171582227 hasRelatedWork W2073792004 @default.
- W3171582227 hasRelatedWork W2142826725 @default.
- W3171582227 hasRelatedWork W2350518114 @default.
- W3171582227 hasRelatedWork W2352753275 @default.
- W3171582227 hasRelatedWork W2375980633 @default.
- W3171582227 hasRelatedWork W2376362945 @default.
- W3171582227 hasRelatedWork W2377185737 @default.
- W3171582227 hasRelatedWork W2399564203 @default.
- W3171582227 hasRelatedWork W3028818078 @default.
- W3171582227 hasRelatedWork W3120235892 @default.
- W3171582227 hasVolume "35" @default.
- W3171582227 isParatext "false" @default.
- W3171582227 isRetracted "false" @default.
- W3171582227 magId "3171582227" @default.
- W3171582227 workType "article" @default.