Matches in SemOpenAlex for { <https://semopenalex.org/work/W3171595911> ?p ?o ?g. }
- W3171595911 endingPage "105068" @default.
- W3171595911 startingPage "105068" @default.
- W3171595911 abstract "There are several potential side and adverse effects are found to be associated with the anti-inflammatory drugs in clinical practice. The long-term use of these clinical agents highly unsafe. It encouraged the development of novel heterocyclic compounds with potential anti-inflammatory activity and low to no toxicity. In present investigation, a total of 12 indole functionalized pyrazole and oxadiazole derivatives were designed, synthesized and evaluated for the in-vivo anti-inflammatory and analgesic potential. These compounds displayed comparable anti-inflammatory and analgesic potential to the reference drugs. Finally, molecular docking analysis was performed considering different anti-inflammatory targets to determine the mechanistic target of the designed molecules. Detailed analysis suggested that the molecules inhibit COX-2, preferably over other anti-inflammatory targets. The results suggested that two compounds (15c and 15f) were found promising candidates for the development of novel anti-inflammatory agents." @default.
- W3171595911 created "2021-06-22" @default.
- W3171595911 creator A5000894956 @default.
- W3171595911 creator A5004042220 @default.
- W3171595911 creator A5007382391 @default.
- W3171595911 creator A5016330457 @default.
- W3171595911 creator A5030817137 @default.
- W3171595911 creator A5086362704 @default.
- W3171595911 date "2021-09-01" @default.
- W3171595911 modified "2023-10-16" @default.
- W3171595911 title "Investigation of indole functionalized pyrazoles and oxadiazoles as anti-inflammatory agents: Synthesis, in-vivo, in-vitro and in-silico analysis" @default.
- W3171595911 cites W1480874656 @default.
- W3171595911 cites W1935912749 @default.
- W3171595911 cites W1964103520 @default.
- W3171595911 cites W1964370181 @default.
- W3171595911 cites W1979020782 @default.
- W3171595911 cites W1980220254 @default.
- W3171595911 cites W1981819970 @default.
- W3171595911 cites W1990067598 @default.
- W3171595911 cites W1991047945 @default.
- W3171595911 cites W2003185617 @default.
- W3171595911 cites W2021912318 @default.
- W3171595911 cites W2025288780 @default.
- W3171595911 cites W2037462205 @default.
- W3171595911 cites W2042433863 @default.
- W3171595911 cites W2063725759 @default.
- W3171595911 cites W2071866045 @default.
- W3171595911 cites W2084347081 @default.
- W3171595911 cites W2089056350 @default.
- W3171595911 cites W2102377211 @default.
- W3171595911 cites W2110771105 @default.
- W3171595911 cites W2118278569 @default.
- W3171595911 cites W2130594874 @default.
- W3171595911 cites W21333867 @default.
- W3171595911 cites W2151534353 @default.
- W3171595911 cites W2222589778 @default.
- W3171595911 cites W2553311818 @default.
- W3171595911 cites W2557945517 @default.
- W3171595911 cites W2783183345 @default.
- W3171595911 cites W2790938954 @default.
- W3171595911 cites W2793621612 @default.
- W3171595911 cites W2891318100 @default.
- W3171595911 cites W2908354566 @default.
- W3171595911 cites W2972830734 @default.
- W3171595911 cites W2991848919 @default.
- W3171595911 cites W2999903268 @default.
- W3171595911 cites W3002016602 @default.
- W3171595911 cites W3014094733 @default.
- W3171595911 cites W3127935100 @default.
- W3171595911 cites W4232036126 @default.
- W3171595911 doi "https://doi.org/10.1016/j.bioorg.2021.105068" @default.
- W3171595911 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34130110" @default.
- W3171595911 hasPublicationYear "2021" @default.
- W3171595911 type Work @default.
- W3171595911 sameAs 3171595911 @default.
- W3171595911 citedByCount "14" @default.
- W3171595911 countsByYear W31715959112022 @default.
- W3171595911 countsByYear W31715959112023 @default.
- W3171595911 crossrefType "journal-article" @default.
- W3171595911 hasAuthorship W3171595911A5000894956 @default.
- W3171595911 hasAuthorship W3171595911A5004042220 @default.
- W3171595911 hasAuthorship W3171595911A5007382391 @default.
- W3171595911 hasAuthorship W3171595911A5016330457 @default.
- W3171595911 hasAuthorship W3171595911A5030817137 @default.
- W3171595911 hasAuthorship W3171595911A5086362704 @default.
- W3171595911 hasConcept C104317684 @default.
- W3171595911 hasConcept C150903083 @default.
- W3171595911 hasConcept C159110408 @default.
- W3171595911 hasConcept C185592680 @default.
- W3171595911 hasConcept C192527728 @default.
- W3171595911 hasConcept C202751555 @default.
- W3171595911 hasConcept C207001950 @default.
- W3171595911 hasConcept C21951064 @default.
- W3171595911 hasConcept C2775905019 @default.
- W3171595911 hasConcept C2777682936 @default.
- W3171595911 hasConcept C2779703632 @default.
- W3171595911 hasConcept C2780820201 @default.
- W3171595911 hasConcept C2909432430 @default.
- W3171595911 hasConcept C41685203 @default.
- W3171595911 hasConcept C55493867 @default.
- W3171595911 hasConcept C71240020 @default.
- W3171595911 hasConcept C71924100 @default.
- W3171595911 hasConcept C86803240 @default.
- W3171595911 hasConcept C98274493 @default.
- W3171595911 hasConceptScore W3171595911C104317684 @default.
- W3171595911 hasConceptScore W3171595911C150903083 @default.
- W3171595911 hasConceptScore W3171595911C159110408 @default.
- W3171595911 hasConceptScore W3171595911C185592680 @default.
- W3171595911 hasConceptScore W3171595911C192527728 @default.
- W3171595911 hasConceptScore W3171595911C202751555 @default.
- W3171595911 hasConceptScore W3171595911C207001950 @default.
- W3171595911 hasConceptScore W3171595911C21951064 @default.
- W3171595911 hasConceptScore W3171595911C2775905019 @default.
- W3171595911 hasConceptScore W3171595911C2777682936 @default.
- W3171595911 hasConceptScore W3171595911C2779703632 @default.
- W3171595911 hasConceptScore W3171595911C2780820201 @default.
- W3171595911 hasConceptScore W3171595911C2909432430 @default.
- W3171595911 hasConceptScore W3171595911C41685203 @default.