FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3171716462> ?p ?o ?g. }

• W3171716462 abstract "Maternal separation (MS), a type of early life stress, has been associated with adverse socioemotional and behavioral outcomes throughout the lifespan across multiple species. Comprehensive longitudinal biobehavioral characterization of MS in rats is sparse and conflicting, warranting more studies. We conducted an MS paradigm involving 6-hour daily separation at unpredictable start times from P2 to P21. We hypothesized this severe form of MS would lead to developmentally emerging maladaptive biobehavioral consequences from juvenile through adult periods compared to Controls (C), especially in social behaviors. We tested: (1) own dam odor preference shortly after weaning; (2) juvenile and adult anxiety-like, sociability, and play behaviors using the light-dark test, three-chambered social interaction test, and video-coded juvenile play behavior; and (3) adult coping behaviors and neuroendocrine response using the forced swim test and blood corticosterone responses. Our results show minimal effects on biobehavioral outcomes across the lifespan. Recently weaned MS male rats had a stronger preference for their dam’s odor. Juvenile MS females spent more time in rough-and-tumble play than C female rats. No differences in sociability were found in the juvenile or adult periods. MS promoted a decrease in anxiety-like behavior that persisted from juvenile to adult periods. Finally, MS led to deficits in coping behavior in male adults, but basal and reactive corticosterone levels were unaltered by MS. More studies are needed to validate our surprising findings and probe the neural mechanisms underlying some of the observed protective effects. Significance Statement Maternal separation (MS), a type of early life stress, has been shown to lead to short and long-term adverse socioemotional consequences in humans and biobehavioral outcomes in rodents. Available data on MS exposed rats are sparse, conflicting, and often lack longitudinal outcomes. We designed a 6-hour unpredictable daily MS paradigm from postnatal day (P2) to P21 to severely disrupt normal dam-pup interactions. Our results show MS leads to increased preference for own dam odor, persisting reductions in anxiety-like behaviors from juvenile to adulthood, and no effects on sociability. Adverse effects on coping behaviors were uniquely identified in males. The present study warrants reevaluation of the central dogma that MS leads to maladaptive biobehavioral outcomes." @default.
• W3171716462 created "2021-06-22" @default.
• W3171716462 creator A5008771900 @default.
• W3171716462 creator A5026709421 @default.
• W3171716462 creator A5027581319 @default.
• W3171716462 creator A5041126882 @default.
• W3171716462 creator A5064701994 @default.
• W3171716462 creator A5066654828 @default.
• W3171716462 creator A5066843270 @default.
• W3171716462 creator A5078047725 @default.
• W3171716462 creator A5082374223 @default.
• W3171716462 creator A5091027496 @default.
• W3171716462 date "2021-06-07" @default.
• W3171716462 modified "2023-10-03" @default.
• W3171716462 title "A severe form of maternal separation in rat consisting of nineteen-day 6-hour daily separation at unpredictable times minimally affects behavior across the lifespan" @default.
• W3171716462 cites W1846668353 @default.
• W3171716462 cites W1944272128 @default.
• W3171716462 cites W1967955744 @default.
• W3171716462 cites W1969909017 @default.
• W3171716462 cites W1972490748 @default.
• W3171716462 cites W1974213686 @default.
• W3171716462 cites W1984439935 @default.
• W3171716462 cites W1986104000 @default.
• W3171716462 cites W1991842644 @default.
• W3171716462 cites W1992874462 @default.
• W3171716462 cites W1994285890 @default.
• W3171716462 cites W1999540956 @default.
• W3171716462 cites W2011562111 @default.
• W3171716462 cites W2013598219 @default.
• W3171716462 cites W2024795975 @default.
• W3171716462 cites W2030260775 @default.
• W3171716462 cites W2038596050 @default.
• W3171716462 cites W2050959523 @default.
• W3171716462 cites W2054692302 @default.
• W3171716462 cites W2055408622 @default.
• W3171716462 cites W2056902640 @default.
• W3171716462 cites W2060159413 @default.
• W3171716462 cites W2063465809 @default.
• W3171716462 cites W2064317748 @default.
• W3171716462 cites W2068144526 @default.
• W3171716462 cites W2068731812 @default.
• W3171716462 cites W2069766673 @default.
• W3171716462 cites W2070173588 @default.
• W3171716462 cites W2070971788 @default.
• W3171716462 cites W2073023788 @default.
• W3171716462 cites W2073104923 @default.
• W3171716462 cites W2081621134 @default.
• W3171716462 cites W2084811491 @default.
• W3171716462 cites W2088450404 @default.
• W3171716462 cites W2089691937 @default.
• W3171716462 cites W2090869890 @default.
• W3171716462 cites W2099042039 @default.
• W3171716462 cites W2110669207 @default.
• W3171716462 cites W2125530468 @default.
• W3171716462 cites W2129526419 @default.
• W3171716462 cites W2135562556 @default.
• W3171716462 cites W2135828915 @default.
• W3171716462 cites W2142364482 @default.
• W3171716462 cites W2145223707 @default.
• W3171716462 cites W2158438953 @default.
• W3171716462 cites W2158631116 @default.
• W3171716462 cites W2166610914 @default.
• W3171716462 cites W2171217262 @default.
• W3171716462 cites W2220132946 @default.
• W3171716462 cites W2315020061 @default.
• W3171716462 cites W2321973374 @default.
• W3171716462 cites W2329170882 @default.
• W3171716462 cites W2330560746 @default.
• W3171716462 cites W2344254260 @default.
• W3171716462 cites W2346059896 @default.
• W3171716462 cites W2366754015 @default.
• W3171716462 cites W2417042551 @default.
• W3171716462 cites W2504691242 @default.
• W3171716462 cites W2506164531 @default.
• W3171716462 cites W2512442953 @default.
• W3171716462 cites W2555294804 @default.
• W3171716462 cites W2557377799 @default.
• W3171716462 cites W2580426974 @default.
• W3171716462 cites W2589698835 @default.
• W3171716462 cites W2599467169 @default.
• W3171716462 cites W2773227887 @default.
• W3171716462 cites W2790610233 @default.
• W3171716462 cites W2795924638 @default.
• W3171716462 cites W2884938665 @default.
• W3171716462 cites W2888665287 @default.
• W3171716462 cites W2889984035 @default.
• W3171716462 cites W2939387110 @default.
• W3171716462 cites W2947332382 @default.
• W3171716462 cites W2994939335 @default.
• W3171716462 cites W3027995492 @default.
• W3171716462 cites W3163223391 @default.
• W3171716462 cites W4243689590 @default.
• W3171716462 cites W4254579407 @default.
• W3171716462 cites W4256000246 @default.
• W3171716462 doi "https://doi.org/10.1101/2021.06.07.447289" @default.
• W3171716462 hasPublicationYear "2021" @default.
• W3171716462 type Work @default.
• W3171716462 sameAs 3171716462 @default.
• W3171716462 citedByCount "0" @default.
• W3171716462 crossrefType "posted-content" @default.

• next