Matches in SemOpenAlex for { <https://semopenalex.org/work/W3171728767> ?p ?o ?g. }
- W3171728767 abstract "Abstract Transcriptionally silent chromatin often localizes to the nuclear periphery. However, whether the nuclear envelope (NE) is a site for post-transcriptional gene repression is unknown. Here we demonstrate that S. pombe Lem2, an NE protein, regulates nuclear exosome-mediated RNA degradation. Lem2 deletion causes accumulation of non-coding RNAs and meiotic transcripts. Indeed, an engineered exosome substrate RNA shows Lem2-dependent localization to the nuclear periphery. Lem2 does not directly bind RNA, but instead physically interacts with the exosome-targeting MTREC complex and promotes RNA recruitment. The Lem2-assisted pathway acts independently of nuclear bodies where exosome factors assemble, revealing that multiple spatially distinct degradation pathways exist. The Lem2 pathway is environmentally responsive: nutrient availability modulates Lem2 regulation of meiotic transcripts. Our data indicate that Lem2 recruits exosome co-factors to the nuclear periphery to coordinate RNA surveillance and regulates transcripts during the mitosis-to-meiosis switch." @default.
- W3171728767 created "2021-06-22" @default.
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- W3171728767 date "2021-05-30" @default.
- W3171728767 modified "2023-10-01" @default.
- W3171728767 title "The inner nuclear membrane protein Lem2 coordinates RNA degradation at the nuclear periphery" @default.
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- W3171728767 doi "https://doi.org/10.1101/2021.05.30.446327" @default.
- W3171728767 hasPublicationYear "2021" @default.
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