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• W3171851320 abstract "Abstract In vertebrates, the anterior pituitary plays a crucial role in regulating several essential physiological processes via the secretion of at least seven peptide hormones by different endocrine cell types. Comparative and comprehensive knowledge of the spatial distribution of those endocrine cell types is required to better understand their role during the animal life. Using medaka as the model and several combinations of multi-color fluorescence in situ hybridization, we present the first 3D atlas revealing the gland-wide distribution of seven endocrine cell populations: lactotropes, thyrotropes, Lh and Fsh gonadotropes, somatotropes, and pomca -expressing cells (corticotropes and melanotropes) in the anterior pituitary of a teleost fish. By combining in situ hybridization and immunofluorescence techniques, we deciphered the location of corticotropes and melanotropes within the pomca -expressing cell population. The 3D localization approach reveals sexual dimorphism of tshba - and pomca -expressing cells in the adult medaka pituitary. Finally, we show the existence of bi-hormonal cells co-expressing lhb-fshb, fshb-tshba and lhb-sl using single-cell transcriptomics analysis and in situ hybridization. This study offers a solid basis for future comparative studies of the teleost pituitary and its developmental plasticity. Highlights - We offer the first 3D atlas of a teleost pituitary, which presents a valuable resource to the endocrinology and model fish community. - The atlas reveals the 3D spatial distribution of the seven endocrine cell types and blood vessels in the juvenile/adult male and female pituitary. - Gene expression for tshba and pomca , as well as the population size of cells expressing these genes, displays obvious sexual dimorphism in the adult medaka pituitary. - Multi-color in situ hybridization and single cell RNA-seq reveal the existence of bi-hormonal cells, co-expressing lhb-fshb, fshb-tshba, lhb-sl , and a few multi-hormonal cells. - An online version of the atlas is available at https://www.nmbu.no/go/mpg-atlas ." @default.
• W3171851320 created "2021-06-22" @default.
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• W3171851320 date "2021-05-31" @default.
• W3171851320 modified "2023-09-26" @default.
• W3171851320 title "3D atlas of the pituitary gland of the model fish medaka" @default.
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• W3171851320 doi "https://doi.org/10.1101/2021.05.31.446412" @default.
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