Matches in SemOpenAlex for { <https://semopenalex.org/work/W3172064972> ?p ?o ?g. }
- W3172064972 endingPage "212" @default.
- W3172064972 startingPage "187" @default.
- W3172064972 abstract "Erectile dysfunction (ED) is one of the most prevalent chronic conditions affecting men. ED can arise from disruptions during development, affecting the patterning of erectile tissues in the penis and/or disruptions in adulthood that impact sexual stimuli, neural pathways, molecular changes, and endocrine signalling that are required to drive erection. Sexual stimulation activates the parasympathetic system which causes nerve terminals in the penis to release nitric oxide (NO). As a result, the penile blood vessels dilate, allowing the penis to engorge with blood. This expansion subsequently compresses the veins surrounding the erectile tissue, restricting venous outflow. As a result, the blood pressure localised in the penis increases dramatically to produce a rigid erection, a process known as tumescence. The sympathetic pathway releases noradrenaline (NA) which causes detumescence: the reversion of the penis to the flaccid state. Androgen signalling is critical for erectile function through its role in penis development and in regulating the physiological processes driving erection in the adult. Interestingly, estrogen signalling is also implicated in penis development and potentially in processes which regulate erectile function during adulthood. Given that endocrine signalling has a prominent role in erectile function, it is likely that exposure to endocrine disrupting chemicals (EDCs) is a risk factor for ED, although this is an under-researched field. Thus, our review provides a detailed description of the underlying biology of erectile function with a focus on the role of endocrine signalling, exploring the potential link between EDCs and ED based on animal and human studies." @default.
- W3172064972 created "2021-06-22" @default.
- W3172064972 creator A5013191248 @default.
- W3172064972 creator A5021054750 @default.
- W3172064972 creator A5087424284 @default.
- W3172064972 date "2021-01-01" @default.
- W3172064972 modified "2023-10-12" @default.
- W3172064972 title "Erectile Dysfunction in Men on the Rise: Is There a Link with Endocrine Disrupting Chemicals?" @default.
- W3172064972 cites W143205812 @default.
- W3172064972 cites W1481930577 @default.
- W3172064972 cites W1482681188 @default.
- W3172064972 cites W1490971947 @default.
- W3172064972 cites W1495512269 @default.
- W3172064972 cites W1501420429 @default.
- W3172064972 cites W1535993237 @default.
- W3172064972 cites W1561857832 @default.
- W3172064972 cites W1586694314 @default.
- W3172064972 cites W1594036338 @default.
- W3172064972 cites W1690772934 @default.
- W3172064972 cites W1718442556 @default.
- W3172064972 cites W1745375268 @default.
- W3172064972 cites W1751387113 @default.
- W3172064972 cites W179619917 @default.
- W3172064972 cites W1827562163 @default.
- W3172064972 cites W1832887128 @default.
- W3172064972 cites W1847582159 @default.
- W3172064972 cites W186068 @default.
- W3172064972 cites W1895318123 @default.
- W3172064972 cites W1925214338 @default.
- W3172064972 cites W1928328877 @default.
- W3172064972 cites W1937438491 @default.
- W3172064972 cites W1960319921 @default.
- W3172064972 cites W1963620624 @default.
- W3172064972 cites W1964445453 @default.
- W3172064972 cites W1965096414 @default.
- W3172064972 cites W1967069595 @default.
- W3172064972 cites W1969777930 @default.
- W3172064972 cites W1973145908 @default.
- W3172064972 cites W1973626130 @default.
- W3172064972 cites W1973702910 @default.
- W3172064972 cites W1974380064 @default.
- W3172064972 cites W1975434964 @default.
- W3172064972 cites W1975636012 @default.
- W3172064972 cites W1977156069 @default.
- W3172064972 cites W1978834230 @default.
- W3172064972 cites W1982235219 @default.
- W3172064972 cites W1984339345 @default.
- W3172064972 cites W1985366927 @default.
- W3172064972 cites W1985813982 @default.
- W3172064972 cites W1987084963 @default.
- W3172064972 cites W1990586673 @default.
- W3172064972 cites W1993917481 @default.
- W3172064972 cites W1994087358 @default.
- W3172064972 cites W1995731007 @default.
- W3172064972 cites W1996698285 @default.
- W3172064972 cites W1997623828 @default.
- W3172064972 cites W1997825003 @default.
- W3172064972 cites W1998621697 @default.
- W3172064972 cites W1999526352 @default.
- W3172064972 cites W2000176464 @default.
- W3172064972 cites W2001610421 @default.
- W3172064972 cites W2002160675 @default.
- W3172064972 cites W2002229396 @default.
- W3172064972 cites W2002430053 @default.
- W3172064972 cites W2004103186 @default.
- W3172064972 cites W2005855834 @default.
- W3172064972 cites W2006324925 @default.
- W3172064972 cites W2007619703 @default.
- W3172064972 cites W2008175469 @default.
- W3172064972 cites W2008734585 @default.
- W3172064972 cites W2009131432 @default.
- W3172064972 cites W2011934538 @default.
- W3172064972 cites W2013892569 @default.
- W3172064972 cites W2015383498 @default.
- W3172064972 cites W2015512055 @default.
- W3172064972 cites W2016779560 @default.
- W3172064972 cites W2016892122 @default.
- W3172064972 cites W2017954678 @default.
- W3172064972 cites W2018398381 @default.
- W3172064972 cites W2018413966 @default.
- W3172064972 cites W2018439057 @default.
- W3172064972 cites W2018600259 @default.
- W3172064972 cites W2021812228 @default.
- W3172064972 cites W2022868203 @default.
- W3172064972 cites W2023810831 @default.
- W3172064972 cites W2025002838 @default.
- W3172064972 cites W2030277526 @default.
- W3172064972 cites W2030465046 @default.
- W3172064972 cites W2030575224 @default.
- W3172064972 cites W2031223162 @default.
- W3172064972 cites W2031224797 @default.
- W3172064972 cites W2031393681 @default.
- W3172064972 cites W2033227204 @default.
- W3172064972 cites W2033860713 @default.
- W3172064972 cites W2036662131 @default.
- W3172064972 cites W2037680901 @default.
- W3172064972 cites W2038759471 @default.
- W3172064972 cites W2038978204 @default.