Matches in SemOpenAlex for { <https://semopenalex.org/work/W3172131041> ?p ?o ?g. }
- W3172131041 endingPage "17" @default.
- W3172131041 startingPage "1" @default.
- W3172131041 abstract "Increasing evidences have revealed that N6-methyladenosine (m6A) RNA methylation regulators participate in the tumorigenesis and development of multiple tumors. So far, there has been little comprehension about the effects of m6A RNA methylation regulators on lower-grade gliomas (LGG). Here, we systematically investigated the expression profiles and prognostic significance of 36 m6A RNA methylation regulators in LGG patients from the TCGA and CGGA databases. Most of the m6A RNA methylation regulators are differentially expressed in LGG tissues as compared with normal brain tissues and glioblastoma (GBM) tissues. The consensus clustering for these m6A RNA methylation regulators identified three clusters. Patients in cluster 3 exhibited worse prognosis. In addition, we constructed an m6A-related prognostic signature, which exhibited excellent performance in prognostic stratification of LGG patients according to the results of the Kaplan-Meier curves, ROC curves, and univariate and multivariate Cox regression analyses. In addition, a significant correlation was observed between the m6A-related prognostic signature and the immune landscape of the LGG microenvironment. The high-risk group exhibited higher immune scores, stromal scores, and ESTIMATE scores but lower tumor purity and lower abundance of activated NK cells. Moreover, the expression level of immune checkpoints was positively correlated with the risk score. To conclude, the current research systematically demonstrated the prognostic roles of m6A RNA methylation regulators in LGG." @default.
- W3172131041 created "2021-06-22" @default.
- W3172131041 creator A5005805630 @default.
- W3172131041 creator A5007348590 @default.
- W3172131041 creator A5008097382 @default.
- W3172131041 creator A5017208132 @default.
- W3172131041 creator A5059545505 @default.
- W3172131041 creator A5066270694 @default.
- W3172131041 creator A5082018758 @default.
- W3172131041 creator A5084988759 @default.
- W3172131041 date "2021-06-08" @default.
- W3172131041 modified "2023-10-17" @default.
- W3172131041 title "Identification of Critical m6A RNA Methylation Regulators with Prognostic Value in Lower-Grade Glioma" @default.
- W3172131041 cites W1812256879 @default.
- W3172131041 cites W1859257957 @default.
- W3172131041 cites W1985987855 @default.
- W3172131041 cites W1991807334 @default.
- W3172131041 cites W2038120157 @default.
- W3172131041 cites W2044685551 @default.
- W3172131041 cites W2049491375 @default.
- W3172131041 cites W2065847836 @default.
- W3172131041 cites W2078964320 @default.
- W3172131041 cites W2115462905 @default.
- W3172131041 cites W2117692326 @default.
- W3172131041 cites W2129925362 @default.
- W3172131041 cites W2130430382 @default.
- W3172131041 cites W2146512944 @default.
- W3172131041 cites W2148977460 @default.
- W3172131041 cites W2546967042 @default.
- W3172131041 cites W2600626962 @default.
- W3172131041 cites W2606742643 @default.
- W3172131041 cites W2754499625 @default.
- W3172131041 cites W2770747479 @default.
- W3172131041 cites W2801400022 @default.
- W3172131041 cites W2804534898 @default.
- W3172131041 cites W2915777758 @default.
- W3172131041 cites W2956132612 @default.
- W3172131041 cites W2972933339 @default.
- W3172131041 cites W2981028350 @default.
- W3172131041 cites W3010860369 @default.
- W3172131041 cites W3016541254 @default.
- W3172131041 cites W3029082514 @default.
- W3172131041 cites W3033161834 @default.
- W3172131041 cites W3041394732 @default.
- W3172131041 cites W3042466763 @default.
- W3172131041 cites W3043284929 @default.
- W3172131041 cites W3044778302 @default.
- W3172131041 cites W3047317536 @default.
- W3172131041 cites W3118401914 @default.
- W3172131041 doi "https://doi.org/10.1155/2021/9959212" @default.
- W3172131041 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8205593" @default.
- W3172131041 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34212046" @default.
- W3172131041 hasPublicationYear "2021" @default.
- W3172131041 type Work @default.
- W3172131041 sameAs 3172131041 @default.
- W3172131041 citedByCount "11" @default.
- W3172131041 countsByYear W31721310412021 @default.
- W3172131041 countsByYear W31721310412022 @default.
- W3172131041 countsByYear W31721310412023 @default.
- W3172131041 crossrefType "journal-article" @default.
- W3172131041 hasAuthorship W3172131041A5005805630 @default.
- W3172131041 hasAuthorship W3172131041A5007348590 @default.
- W3172131041 hasAuthorship W3172131041A5008097382 @default.
- W3172131041 hasAuthorship W3172131041A5017208132 @default.
- W3172131041 hasAuthorship W3172131041A5059545505 @default.
- W3172131041 hasAuthorship W3172131041A5066270694 @default.
- W3172131041 hasAuthorship W3172131041A5082018758 @default.
- W3172131041 hasAuthorship W3172131041A5084988759 @default.
- W3172131041 hasBestOaLocation W31721310411 @default.
- W3172131041 hasConcept C104317684 @default.
- W3172131041 hasConcept C121608353 @default.
- W3172131041 hasConcept C126322002 @default.
- W3172131041 hasConcept C143998085 @default.
- W3172131041 hasConcept C150194340 @default.
- W3172131041 hasConcept C16930146 @default.
- W3172131041 hasConcept C190727270 @default.
- W3172131041 hasConcept C203014093 @default.
- W3172131041 hasConcept C2775963939 @default.
- W3172131041 hasConcept C2778227246 @default.
- W3172131041 hasConcept C2909856833 @default.
- W3172131041 hasConcept C33288867 @default.
- W3172131041 hasConcept C502942594 @default.
- W3172131041 hasConcept C50382708 @default.
- W3172131041 hasConcept C54355233 @default.
- W3172131041 hasConcept C555283112 @default.
- W3172131041 hasConcept C62203573 @default.
- W3172131041 hasConcept C67705224 @default.
- W3172131041 hasConcept C71924100 @default.
- W3172131041 hasConcept C86803240 @default.
- W3172131041 hasConcept C8891405 @default.
- W3172131041 hasConcept C91965660 @default.
- W3172131041 hasConceptScore W3172131041C104317684 @default.
- W3172131041 hasConceptScore W3172131041C121608353 @default.
- W3172131041 hasConceptScore W3172131041C126322002 @default.
- W3172131041 hasConceptScore W3172131041C143998085 @default.
- W3172131041 hasConceptScore W3172131041C150194340 @default.
- W3172131041 hasConceptScore W3172131041C16930146 @default.
- W3172131041 hasConceptScore W3172131041C190727270 @default.