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- W3172167773 abstract "Abstract The iron gall ink-triggered chemical corrosion of hand-written documents is a big threat to Western cultural heritages, which was demonstrated to result from the iron gall (GA-Fe) chelate-promoted reactive oxygen species generation. Such a phenomenon has inspired us to apply the pro-oxidative mechanism of GA-Fe to anticancer therapy. In this work, we construct a composite cancer nanomedicine by loading gallate into a Fe-engineered mesoporous silica nanocarrier, which can degrade in acidic tumor to release the doped Fe 3+ and the loaded gallate, forming GA-Fe nanocomplex in situ. The nanocomplex with a highly reductive ligand field can promote oxygen reduction reactions generating hydrogen peroxide. Moreover, the resultant two-electron oxidation form of GA-Fe is an excellent Fenton-like agent that can catalyze hydrogen peroxide decomposition into hydroxyl radical, finally triggering severe oxidative damage to tumors. Such a therapeutic approach by intratumoral synthesis of GA-Fe nano-metalchelate may be instructive to future anticancer researches." @default.
- W3172167773 created "2021-06-22" @default.
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- W3172167773 date "2021-06-07" @default.
- W3172167773 modified "2023-10-12" @default.
- W3172167773 title "Intratumoral synthesis of nano-metalchelate for tumor catalytic therapy by ligand field-enhanced coordination" @default.
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- W3172167773 doi "https://doi.org/10.1038/s41467-021-23710-y" @default.
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