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- W3172175854 abstract "Human PCID2, is characterized by its PCI interaction domain and its involvement in the mammalian transcription export complex, TREX-2. One component of the TREX-2 complex, Centrin-2, is known to be involved in protein export in addition to mRNA export and was originally identified as a component of the centrosome. We attempted to determine if PCID2 also performs these other functions in the cell. We have demonstrated that PCID2 colocalizes with γ-tubulin and centrin-2 at the centrosome of HeLa cells. Furthermore, knockdown of PCID2, while not affecting nuclear protein import, does lead to a delay in nuclear protein export. In contrast we have demonstrated that another TREX-2 component, Eny2, is not present at the centrosome nor is it involved in nuclear protein transport. Therefore, our results indicate that PCID2 distinctly serves roles outside of the TREX-2 complex that parallel the function of Centrin-2." @default.
- W3172175854 created "2021-06-22" @default.
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- W3172175854 date "2013-04-01" @default.
- W3172175854 modified "2023-09-23" @default.
- W3172175854 title "Human PCID2 plays analogous roles to Centrin 2 outside of the TREX‐2 complex." @default.
- W3172175854 doi "https://doi.org/10.1096/fasebj.27.1_supplement.767.1" @default.
- W3172175854 hasPublicationYear "2013" @default.
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