FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3172181161> ?p ?o ?g. }

• W3172181161 endingPage "6319" @default.
• W3172181161 startingPage "6319" @default.
• W3172181161 abstract "Transposable elements (TEs) are repetitive elements that belong to a variety of functional classes and have an important role in shaping genome evolution. Around 50% of the human genome contains TEs, and they have been termed the “dark matter” of the genome because relatively little is known about their function. While TEs have been shown to participate in aberrant gene regulation and the pathogenesis of diseases, only a few studies have explored the systemic effect of TEs on gene expression. In the present study, we analysed whole genome sequences and blood whole transcriptome data from 570 individuals within the Parkinson’s Progressive Markers Initiative (PPMI) cohort to identify expression quantitative trait loci (eQTL) regulating genome-wide gene expression associated with TEs. We identified 2132 reference TEs that were polymorphic for their presence or absence in our study cohort. The presence or absence of the TE element could change the expression of the gene or gene clusters from zero to tens of thousands of copies of RNA. The main finding is that many TEs possess very strong regulatory effects, and they have the potential to modulate large genetic networks with hundreds of target genes over the genome. We illustrate the plethora of regulatory mechanisms using examples of their action at the HLA gene cluster and data showing different TEs’ convergence to modulate WFS1 gene expression. In conclusion, the presence or absence of polymorphisms of TEs has an eminent genome-wide regulatory function with large effect size at the level of the whole transcriptome. The role of TEs in explaining, in part, the missing heritability for complex traits is convincing and should be considered." @default.
• W3172181161 created "2021-06-22" @default.
• W3172181161 creator A5037656140 @default.
• W3172181161 creator A5037963150 @default.
• W3172181161 creator A5061510230 @default.
• W3172181161 creator A5063620741 @default.
• W3172181161 date "2021-06-12" @default.
• W3172181161 modified "2023-09-29" @default.
• W3172181161 title "Expression Quantitative Trait Loci (eQTLs) Associated with Retrotransposons Demonstrate their Modulatory Effect on the Transcriptome" @default.
• W3172181161 cites W1967919664 @default.
• W3172181161 cites W1980369994 @default.
• W3172181161 cites W2023453519 @default.
• W3172181161 cites W2028297147 @default.
• W3172181161 cites W2040741651 @default.
• W3172181161 cites W2042086471 @default.
• W3172181161 cites W2046432787 @default.
• W3172181161 cites W2051541780 @default.
• W3172181161 cites W2059864757 @default.
• W3172181161 cites W2062098224 @default.
• W3172181161 cites W2067364305 @default.
• W3172181161 cites W2069955967 @default.
• W3172181161 cites W2072420737 @default.
• W3172181161 cites W2079655012 @default.
• W3172181161 cites W2096652998 @default.
• W3172181161 cites W2097535113 @default.
• W3172181161 cites W2100697281 @default.
• W3172181161 cites W2107333779 @default.
• W3172181161 cites W2137702285 @default.
• W3172181161 cites W2139367243 @default.
• W3172181161 cites W2161633633 @default.
• W3172181161 cites W2165743231 @default.
• W3172181161 cites W2167568530 @default.
• W3172181161 cites W2331404411 @default.
• W3172181161 cites W2565657638 @default.
• W3172181161 cites W2626923045 @default.
• W3172181161 cites W2750782486 @default.
• W3172181161 cites W2751819051 @default.
• W3172181161 cites W2768492030 @default.
• W3172181161 cites W2775493833 @default.
• W3172181161 cites W2788135418 @default.
• W3172181161 cites W2791406732 @default.
• W3172181161 cites W2792972070 @default.
• W3172181161 cites W2793948658 @default.
• W3172181161 cites W2920965957 @default.
• W3172181161 cites W2990399210 @default.
• W3172181161 cites W3036325257 @default.
• W3172181161 cites W3041568474 @default.
• W3172181161 cites W3084155524 @default.
• W3172181161 cites W3084576355 @default.
• W3172181161 cites W3094690363 @default.
• W3172181161 cites W3099277425 @default.
• W3172181161 cites W3112725876 @default.
• W3172181161 cites W3138556183 @default.
• W3172181161 cites W3148294016 @default.
• W3172181161 doi "https://doi.org/10.3390/ijms22126319" @default.
• W3172181161 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8231655" @default.
• W3172181161 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34204806" @default.
• W3172181161 hasPublicationYear "2021" @default.
• W3172181161 type Work @default.
• W3172181161 sameAs 3172181161 @default.
• W3172181161 citedByCount "6" @default.
• W3172181161 countsByYear W31721811612021 @default.
• W3172181161 countsByYear W31721811612022 @default.
• W3172181161 countsByYear W31721811612023 @default.
• W3172181161 crossrefType "journal-article" @default.
• W3172181161 hasAuthorship W3172181161A5037656140 @default.
• W3172181161 hasAuthorship W3172181161A5037963150 @default.
• W3172181161 hasAuthorship W3172181161A5061510230 @default.
• W3172181161 hasAuthorship W3172181161A5063620741 @default.
• W3172181161 hasBestOaLocation W31721811611 @default.
• W3172181161 hasConcept C104317684 @default.
• W3172181161 hasConcept C106208931 @default.
• W3172181161 hasConcept C135763542 @default.
• W3172181161 hasConcept C141231307 @default.
• W3172181161 hasConcept C150194340 @default.
• W3172181161 hasConcept C153209595 @default.
• W3172181161 hasConcept C162317418 @default.
• W3172181161 hasConcept C165864922 @default.
• W3172181161 hasConcept C168393362 @default.
• W3172181161 hasConcept C197077220 @default.
• W3172181161 hasConcept C4918238 @default.
• W3172181161 hasConcept C54355233 @default.
• W3172181161 hasConcept C7029365 @default.
• W3172181161 hasConcept C70721500 @default.
• W3172181161 hasConcept C86803240 @default.
• W3172181161 hasConceptScore W3172181161C104317684 @default.
• W3172181161 hasConceptScore W3172181161C106208931 @default.
• W3172181161 hasConceptScore W3172181161C135763542 @default.
• W3172181161 hasConceptScore W3172181161C141231307 @default.
• W3172181161 hasConceptScore W3172181161C150194340 @default.
• W3172181161 hasConceptScore W3172181161C153209595 @default.
• W3172181161 hasConceptScore W3172181161C162317418 @default.
• W3172181161 hasConceptScore W3172181161C165864922 @default.
• W3172181161 hasConceptScore W3172181161C168393362 @default.
• W3172181161 hasConceptScore W3172181161C197077220 @default.
• W3172181161 hasConceptScore W3172181161C4918238 @default.
• W3172181161 hasConceptScore W3172181161C54355233 @default.
• W3172181161 hasConceptScore W3172181161C7029365 @default.

• next