Matches in SemOpenAlex for { <https://semopenalex.org/work/W3172185344> ?p ?o ?g. }
Showing items 1 to 62 of
62
with 100 items per page.
- W3172185344 abstract "Hox11 genes are expressed around the developing wrist and ankle and are known to substantially impact pisiform shape and length in mice. The calcaneus is a tarsal bone that is paralogous to the pisiform in the wrist, but previous descriptions of mice with Hox11 mutations have suggested that little morphological change takes place unless Hoxa11 and Hoxd11 are both knocked out, at which point the calcaneus fails to form. However, these studies primarily relied on cleared and stained whole-mount specimens which limit resolution of morphological features. This study seeks to determine if calcaneus morphology is altered by three or fewer loss-of-function Hoxa11 and Hoxd11 alleles. We obtained microCT scans of 8 week old mice and compared calcaneus morphology in wild type mice and mice with one, two, and three Hoxa11 and Hoxd11 loss-of-function alleles. We used auto3dgm to conduct a 3D geometric morphometric analysis of shape variation using surface semi-landmarks. Principle components (PC) analysis indicates that calcaneus morphology is altered in mice with Hoxa11 and Hoxd11 loss-of-function mutations. PC1 accounts for 35.4% of shape variation and results from changes to the width and height of the calcaneal neck and shape of peroneal tubercle/process. PC2 accounts for 11.9% of shape variation and results from changes to the width of the calcaneal tuberosity and height of the posterior talar facet. Most specimens with either combination of three out of four Hoxa11 and Hoxd11 loss-of-function alleles cluster together. The other genotypes form a gradient of morphological change with WT, Hoxd11 heterozygotes, and Hoxd11 knockouts being most similar to each other and Hoxa11 heterozygotes, Hoxa11 knockouts, and heterozygotes for both genes being most similar to each other. These results suggest that Hox11 loss-of-function mutations result in altered calcaneus morphology and Hoxa11 and Hoxd11 loss-of-function mutations alter the shape of the calcaneus in different ways when fewer than three alleles are knocked out." @default.
- W3172185344 created "2021-06-22" @default.
- W3172185344 creator A5003557986 @default.
- W3172185344 creator A5021111044 @default.
- W3172185344 creator A5024206533 @default.
- W3172185344 creator A5060655912 @default.
- W3172185344 creator A5063958129 @default.
- W3172185344 creator A5066850696 @default.
- W3172185344 creator A5085183365 @default.
- W3172185344 creator A5088172050 @default.
- W3172185344 date "2021-05-01" @default.
- W3172185344 modified "2023-10-15" @default.
- W3172185344 title "Morphological Changes in Calcanei of Mice with Hoxa11 and Hoxd11 loss‐of‐function mutations" @default.
- W3172185344 doi "https://doi.org/10.1096/fasebj.2021.35.s1.03175" @default.
- W3172185344 hasPublicationYear "2021" @default.
- W3172185344 type Work @default.
- W3172185344 sameAs 3172185344 @default.
- W3172185344 citedByCount "0" @default.
- W3172185344 crossrefType "journal-article" @default.
- W3172185344 hasAuthorship W3172185344A5003557986 @default.
- W3172185344 hasAuthorship W3172185344A5021111044 @default.
- W3172185344 hasAuthorship W3172185344A5024206533 @default.
- W3172185344 hasAuthorship W3172185344A5060655912 @default.
- W3172185344 hasAuthorship W3172185344A5063958129 @default.
- W3172185344 hasAuthorship W3172185344A5066850696 @default.
- W3172185344 hasAuthorship W3172185344A5085183365 @default.
- W3172185344 hasAuthorship W3172185344A5088172050 @default.
- W3172185344 hasBestOaLocation W31721853441 @default.
- W3172185344 hasConcept C104317684 @default.
- W3172185344 hasConcept C105951970 @default.
- W3172185344 hasConcept C127716648 @default.
- W3172185344 hasConcept C14036430 @default.
- W3172185344 hasConcept C501734568 @default.
- W3172185344 hasConcept C54355233 @default.
- W3172185344 hasConcept C86803240 @default.
- W3172185344 hasConceptScore W3172185344C104317684 @default.
- W3172185344 hasConceptScore W3172185344C105951970 @default.
- W3172185344 hasConceptScore W3172185344C127716648 @default.
- W3172185344 hasConceptScore W3172185344C14036430 @default.
- W3172185344 hasConceptScore W3172185344C501734568 @default.
- W3172185344 hasConceptScore W3172185344C54355233 @default.
- W3172185344 hasConceptScore W3172185344C86803240 @default.
- W3172185344 hasFunder F4320306076 @default.
- W3172185344 hasIssue "S1" @default.
- W3172185344 hasLocation W31721853441 @default.
- W3172185344 hasOpenAccess W3172185344 @default.
- W3172185344 hasPrimaryLocation W31721853441 @default.
- W3172185344 hasRelatedWork W1987535520 @default.
- W3172185344 hasRelatedWork W2060093638 @default.
- W3172185344 hasRelatedWork W2074557329 @default.
- W3172185344 hasRelatedWork W2088263708 @default.
- W3172185344 hasRelatedWork W2106452870 @default.
- W3172185344 hasRelatedWork W2170309221 @default.
- W3172185344 hasRelatedWork W2366111644 @default.
- W3172185344 hasRelatedWork W2734891494 @default.
- W3172185344 hasRelatedWork W3177469942 @default.
- W3172185344 hasRelatedWork W3195241902 @default.
- W3172185344 hasVolume "35" @default.
- W3172185344 isParatext "false" @default.
- W3172185344 isRetracted "false" @default.
- W3172185344 magId "3172185344" @default.
- W3172185344 workType "article" @default.