FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3172204172> ?p ?o ?g. }

• W3172204172 endingPage "1044" @default.
• W3172204172 startingPage "1044" @default.
• W3172204172 abstract "Gingival squamous cell carcinoma (SCC) frequently invades the maxillary or mandibular bone, and bone destruction is known as a key prognostic factor in gingival SCCs. Recently, Neurokinin 3 receptor (NK-3R), the receptor ligand for NK-3, which is a member of the tachykinin family expressed in the central nervous system, was identified through pathway analysis as a molecule expressed in osteoclasts induced by the hedgehog signal. Although the expression of NK-3R has been detected in osteoclast and SCC cells at the bone invasion front, the relationship between NK-3R expression and the prognosis of gingival SCC patients remains unclear. In the present study, we retrospectively reviewed 27 patients with gingival SCC who had undergone surgery with curative intent. Significantly higher NK-3R expression in tumor cells was found in a case of jawbone invasion than in a case of exophytic poor jawbone invasion. On the other hand, no significant association was observed between NK-3R tumor-positive cases and tumor size, TNM stage, or tumor differentiation. The survival rate tended to be lower in NK-3R tumor-positive cases, but not significantly. However, the disease-specific survival rate was significantly lower in patients with a large number of NK-3R-positive osteoclasts than in those with a small number of them at the tumor bone invasion front. Our results suggest that NK-3R signaling in the gingival SCC bone microenvironment plays an important role in tumor bone destruction and should be considered a potential therapeutic target in advanced gingival SCC with bone destruction." @default.
• W3172204172 created "2021-06-22" @default.
• W3172204172 creator A5008747331 @default.
• W3172204172 creator A5010712769 @default.
• W3172204172 creator A5012846504 @default.
• W3172204172 creator A5015429847 @default.
• W3172204172 creator A5037500648 @default.
• W3172204172 creator A5041797516 @default.
• W3172204172 creator A5046401386 @default.
• W3172204172 creator A5058063773 @default.
• W3172204172 creator A5058169065 @default.
• W3172204172 creator A5071604185 @default.
• W3172204172 date "2021-06-07" @default.
• W3172204172 modified "2023-10-16" @default.
• W3172204172 title "Expression of Neurokinin B Receptor in the Gingival Squamous Cell Carcinoma Bone Microenvironment" @default.
• W3172204172 cites W1547835751 @default.
• W3172204172 cites W1684101339 @default.
• W3172204172 cites W1766121781 @default.
• W3172204172 cites W1929164123 @default.
• W3172204172 cites W1965931168 @default.
• W3172204172 cites W1966777009 @default.
• W3172204172 cites W1971727102 @default.
• W3172204172 cites W1981951751 @default.
• W3172204172 cites W1992019708 @default.
• W3172204172 cites W2022586856 @default.
• W3172204172 cites W2026815880 @default.
• W3172204172 cites W2035636765 @default.
• W3172204172 cites W2046178008 @default.
• W3172204172 cites W2050464732 @default.
• W3172204172 cites W2054300900 @default.
• W3172204172 cites W2066524898 @default.
• W3172204172 cites W2078228712 @default.
• W3172204172 cites W2080362395 @default.
• W3172204172 cites W2092827845 @default.
• W3172204172 cites W2108746381 @default.
• W3172204172 cites W2123686757 @default.
• W3172204172 cites W2146014366 @default.
• W3172204172 cites W2156573769 @default.
• W3172204172 cites W2168914852 @default.
• W3172204172 cites W2278878920 @default.
• W3172204172 cites W2304547156 @default.
• W3172204172 cites W2388182908 @default.
• W3172204172 cites W2500605922 @default.
• W3172204172 cites W2520178405 @default.
• W3172204172 cites W2538665062 @default.
• W3172204172 cites W2562079402 @default.
• W3172204172 cites W2566058159 @default.
• W3172204172 cites W2587900518 @default.
• W3172204172 cites W2589005813 @default.
• W3172204172 cites W2595857857 @default.
• W3172204172 cites W2607051027 @default.
• W3172204172 cites W2736977335 @default.
• W3172204172 cites W2774236853 @default.
• W3172204172 cites W2801390849 @default.
• W3172204172 cites W2809413450 @default.
• W3172204172 cites W2900400928 @default.
• W3172204172 cites W2901554583 @default.
• W3172204172 cites W2902305910 @default.
• W3172204172 cites W2904435401 @default.
• W3172204172 cites W2909109366 @default.
• W3172204172 cites W2913784762 @default.
• W3172204172 cites W2969238958 @default.
• W3172204172 cites W2970403581 @default.
• W3172204172 cites W2972036828 @default.
• W3172204172 cites W2979308369 @default.
• W3172204172 cites W3008528591 @default.
• W3172204172 cites W3008557223 @default.
• W3172204172 cites W3011452564 @default.
• W3172204172 cites W3015763131 @default.
• W3172204172 cites W3016864385 @default.
• W3172204172 cites W3028300682 @default.
• W3172204172 cites W3035728583 @default.
• W3172204172 cites W3096271455 @default.
• W3172204172 doi "https://doi.org/10.3390/diagnostics11061044" @default.
• W3172204172 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8229468" @default.
• W3172204172 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34200131" @default.
• W3172204172 hasPublicationYear "2021" @default.
• W3172204172 type Work @default.
• W3172204172 sameAs 3172204172 @default.
• W3172204172 citedByCount "0" @default.
• W3172204172 crossrefType "journal-article" @default.
• W3172204172 hasAuthorship W3172204172A5008747331 @default.
• W3172204172 hasAuthorship W3172204172A5010712769 @default.
• W3172204172 hasAuthorship W3172204172A5012846504 @default.
• W3172204172 hasAuthorship W3172204172A5015429847 @default.
• W3172204172 hasAuthorship W3172204172A5037500648 @default.
• W3172204172 hasAuthorship W3172204172A5041797516 @default.
• W3172204172 hasAuthorship W3172204172A5046401386 @default.
• W3172204172 hasAuthorship W3172204172A5058063773 @default.
• W3172204172 hasAuthorship W3172204172A5058169065 @default.
• W3172204172 hasAuthorship W3172204172A5071604185 @default.
• W3172204172 hasBestOaLocation W31722041721 @default.
• W3172204172 hasConcept C121608353 @default.
• W3172204172 hasConcept C126322002 @default.
• W3172204172 hasConcept C142724271 @default.
• W3172204172 hasConcept C170493617 @default.
• W3172204172 hasConcept C2776033226 @default.
• W3172204172 hasConcept C2776107976 @default.

• next