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• W3172320772 endingPage "1446" @default.
• W3172320772 startingPage "1446" @default.
• W3172320772 abstract "Both calcium-independent phospholipase A2 beta (iPLA2β) and endoplasmic reticulum (ER) stress regulate important pathophysiological processes including inflammation, calcium homeostasis and apoptosis. However, their roles in ischemic heart disease are poorly understood. Here, we show that the expression of iPLA2β is increased during myocardial ischemia/reperfusion (I/R) injury, concomitant with the induction of ER stress and the upregulation of cell death. We further show that the levels of iPLA2β in serum collected from acute myocardial infarction (AMI) patients and in samples collected from both in vivo and in vitro I/R injury models are significantly elevated. Further, iPLA2β knockout mice and siRNA mediated iPLA2β knockdown are employed to evaluate the ER stress and cell apoptosis during I/R injury. Additionally, cell surface protein biotinylation and immunofluorescence assays are used to trace and locate iPLA2β. Our data demonstrate the increase of iPLA2β augments ER stress and enhances cardiomyocyte apoptosis during I/R injury in vitro and in vivo. Inhibition of iPLA2β ameliorates ER stress and decreases cell death. Mechanistically, iPLA2β promotes ER stress and apoptosis by translocating to ER upon myocardial I/R injury. Together, our study suggests iPLA2β contributes to ER stress-induced apoptosis during myocardial I/R injury, which may serve as a potential therapeutic target against ischemic heart disease." @default.
• W3172320772 created "2021-06-22" @default.
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• W3172320772 date "2021-06-09" @default.
• W3172320772 modified "2023-10-10" @default.
• W3172320772 title "iPLA2β Contributes to ER Stress-Induced Apoptosis during Myocardial Ischemia/Reperfusion Injury" @default.
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• W3172320772 doi "https://doi.org/10.3390/cells10061446" @default.
• W3172320772 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8227999" @default.
• W3172320772 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34207793" @default.
• W3172320772 hasPublicationYear "2021" @default.
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