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- W3172380710 abstract "To investigate changes in maternal hemodynamics and arterial stiffness throughout pregnancy, in women with pre-existing diabetes mellitus (DM). This was a cross-sectional study, comparing women with type 1 (T1) or type 2 (T2) DM, with low-risk controls, matched for gestational age. We included women with T1 or T2 DM with singleton pregnancies, attending antenatal clinics at Leicester Royal Infirmary (n = 31). Results were compared to controls (n = 78), using parametric and non-parametric tests. Measurements of stroke volume (SV), cardiac output (CO), total peripheral resistance (TPR), systolic and diastolic blood pressure (BP), heart rate (HR) and arterial stiffness, measured by aortic pulse wave velocity (PWVao), were taken at four pre-specified gestational windows (11-19+6, 20-27+6, 28-33+6, ≥34 weeks), using the Non-Invasive Cardiac Output Monitor™ and Arteriograph®. 63 data sets were obtained from women with pre-existing DM and 80 data sets from the control group. Systolic BP, diastolic BP and mean arterial pressure was higher in women with DM compared to controls, reaching significance at 11–19+6 weeks and 28–33+6 weeks (p < 0.01). HR was higher in those with DM than controls, reaching statistical significance at 20–27+6 weeks, 28–33+6 weeks and ≥34 weeks (p < 0.05). No significant differences were seen in SV, CO or TPR in any of the gestational windows (p>0.05). PWVao was found to be consistently higher amongst pregnant women with pre-existing DM than in low-risk controls throughout pregnancy, reaching statistical significance at 20–27+6 and ≥34 weeks of gestation (p < 0.001). Our results demonstrate that pregnant women with T1 and T2 DM possess different hemodynamics to low-risk controls, reflected in raised systolic and diastolic pressures and HR throughout pregnancy. A larger, longitudinal study is required to assess the patterns in hemodynamics and the value of arterial stiffness measurements as a prognostic marker for pregnancy complications in this population." @default.
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- W3172380710 date "2020-10-01" @default.
- W3172380710 modified "2023-09-26" @default.
- W3172380710 title "VP48.05: Maternal hemodynamics and arterial stiffness in pregnant women with type 1 and type 2 diabetes mellitus: a cross‐sectional study" @default.
- W3172380710 doi "https://doi.org/10.1002/uog.23170" @default.
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