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- W3172401558 abstract "Dynamic protein-protein interactions are essential for proper cell functioning. Homo-interaction events-physical interactions between the same type of proteins-represent a pivotal subset of protein-protein interactions that are widely exploited in activating intracellular signaling pathways. Capacities of modulating protein-protein interactions with spatial and temporal resolution are greatly desired to decipher the dynamic nature of signal transduction mechanisms. The emerging optogenetic technology, based on genetically encoded light-sensitive proteins, provides promising opportunities to dissect the highly complex signaling networks with unmatched specificity and spatiotemporal precision. Here we review recent achievements in the development of optogenetic tools enabling light-inducible protein-protein homo-interactions and their applications in optical activation of signaling pathways." @default.
- W3172401558 created "2021-06-22" @default.
- W3172401558 creator A5015899496 @default.
- W3172401558 creator A5057588070 @default.
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- W3172401558 date "2022-01-01" @default.
- W3172401558 modified "2023-10-18" @default.
- W3172401558 title "Optogenetic activation of intracellular signaling based on light-inducible protein-protein homo-interactions" @default.
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- W3172401558 doi "https://doi.org/10.4103/1673-5374.314293" @default.
- W3172401558 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8451544" @default.
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- W3172401558 hasPublicationYear "2022" @default.
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