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- W3172416213 abstract "Oncolytic virotherapy (OV) is an emerging class of immunotherapeutic drugs. Their mechanism of action is two-fold: direct cell lysis and unmasking of the cancer through immunogenic cell death, which allows the immune system to recognize and eradicate tumours. Breast cancer is the most common cancer in women and is challenging to treat with immunotherapy modalities because it is classically an immunogenically “cold” tumour type. This provides an attractive niche for OV, given viruses have been shown to turn “cold” tumours “hot,” thereby opening a plethora of treatment opportunities. There has been a number of pre-clinical attempts to explore the use of OV in breast cancer; however, these have not led to any meaningful clinical trials. This review considers both the potential and the barriers to OV in breast cancer, namely, the limitations of monotherapy and the scope for combination therapy, improving viral delivery and challenges specific to the breast cancer population (e.g., tumour subtype, menopausal status, age)." @default.
- W3172416213 created "2021-06-22" @default.
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- W3172416213 date "2021-06-11" @default.
- W3172416213 modified "2023-10-14" @default.
- W3172416213 title "Oncolytic Virotherapy Treatment of Breast Cancer: Barriers and Recent Advances" @default.
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- W3172416213 cites W1978103330 @default.
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- W3172416213 cites W1990099678 @default.
- W3172416213 cites W1991928654 @default.
- W3172416213 cites W1991941102 @default.
- W3172416213 cites W1993412993 @default.
- W3172416213 cites W1994520101 @default.
- W3172416213 cites W2012150814 @default.
- W3172416213 cites W2036716735 @default.
- W3172416213 cites W2060294539 @default.
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- W3172416213 cites W2103156714 @default.
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- W3172416213 doi "https://doi.org/10.3390/v13061128" @default.
- W3172416213 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8230950" @default.
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