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- W3172491683 abstract "Abstract Background and Aims Idiopathic membranous nephropathy (IMN) is an organ-specific autoimmune disease of the kidney glomerulus. Although substantial advances have been made in the understanding of the molecular bases of IMN in the last 10 years, there remain largely unanswered questions. Method To define the transcriptomic landscape at the single-cell resolution, we analyzed kidney samples from 6 patients with idiopathic membranous nephropathy (IMN) and 2 healthy control subjects using single-cell RNA sequencing. Results Based on transcriptional expression patterns, we identified all previously described cell types in the kidney. Also, we identified a novel population of the epithelial cell which is mainly from IMN patients. GO enrichment analysis showed that DEGs were enriched in the regulation of apoptosis and type I interferon signaling pathway in mesangial cells, while DEGs were enriched in the regulation of programmed cell death, and various cytokine-mediated signaling pathway in endothelial cells and the regulation of protein modification in pericytes. KEGG enrichment analysis revealed that DEGs were mainly associated with the IL-17 signaling pathway, TNF signaling pathway, NOD-like receptor signaling pathway as well as MAPK signaling pathway in endothelial cells as well as pericytes DEGs of proximal tubules cells (PT) and PCs between IMN and control subjects were both enriched in IL-17 signaling, TNF signaling, NOD-like receptor signaling. Moreover, the cell-cell crosstalk highlighted the extensive communication of mesangial cells, which infers great importance in IMN. IMN with massive proteinuria displayed elevated genes participating in the inflammatory signaling pathways that may be involved in the pathogenesis of the progression of IMN. Conclusion Overall, we applied single-cell RNA sequencing to IMN to uncover intercellular interactions, elucidate key pathways underlying the pathogenesis, and identify novel therapeutic targets of IMN." @default.
- W3172491683 created "2021-06-22" @default.
- W3172491683 creator A5009928424 @default.
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- W3172491683 date "2021-05-01" @default.
- W3172491683 modified "2023-09-24" @default.
- W3172491683 title "MO124THE SINGLE-CELL TRANSCRIPTOMIC OF HUMAN IDIOPATHIC MEMBRANOUS NEPHROPATHY*" @default.
- W3172491683 doi "https://doi.org/10.1093/ndt/gfab092.002" @default.
- W3172491683 hasPublicationYear "2021" @default.
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