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- W3172532703 abstract "Background: Our prior work has shown that ambient ozone (O3) is associated with the human gut microbiome. Given that up to 66% of circulating metabolites are associated with at least one gut bacterial taxon, this study aimed to explore the hypothesis that O3 exposure is associated with circulating metabolites via the gut microbiome.Methods: This study was performed in 93 young adults (18-21 years) from the Southern California Children’s Health Study who had available data for prior year 24-hour O3 exposure estimated from central site monitors, the gut microbiome via shotgun sequencing, and fasting serum concentrations of 64 metabolites. Principal component (PC) analysis identified the top three metabolite clusters that represented short- and medium-chain acylcarnitines (PC1), non-esterified fatty acids and its oxidation by-products (PC2) and branched-chain amino-acid catabolism (PC3). FDR adjusted p-values are shown for Kendall correlations and results from mediation analyses are reported.Results: Higher O3 was associated with a lower relative abundance of 434 gut bacterial genera and 318 gut bacterial species (p<0.10). O3 was only associated with PC1 (p=0.046, r=0.21) and PC2 (p=0.046, r=-0.20). Among bacterial genera associated with O3, 14 were negatively associated with PC1 metabolites (C8, C10:1, C10:2, C10:3, C12, C14:1-OH). One gut bacterial pathway, dTDP-L-rhamnose biosynthesis I, was enriched with higher O3 (p=0.059, r=0.24) and was correlated with C14:1-OH (p=0.04, r=0.28) and C12 (p=0.068, r=0.26). Lastly, these taxa appeared to mediate associations between O3 and PC1 (p<0.05). Potential confounders (body mass index, socioeconomic status, energy intake) were not associated with both the gut microbiome and PCs.Conclusion: This preliminary analysis suggests that greater O3 exposure could potentiate adverse effects on mitochondrial fatty acid metabolism among young adults, which may increase the risk for metabolic diseases. While this effect may be mediated by alterations to the gut microbiome, additional work integrating multi-omics measures is needed." @default.
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- W3172532703 date "2020-10-26" @default.
- W3172532703 modified "2023-10-16" @default.
- W3172532703 title "The Gut Microbiome Contributes to the Association Between Ozone Exposure and Fatty Acid Oxidation" @default.
- W3172532703 doi "https://doi.org/10.1289/isee.2020.virtual.p-0038" @default.
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