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- W3172548148 abstract "Abstract The rapid emergence of drug resistant Staphylococcus aureus ( S. aureus ) poses a serious threat to public health globally. Silver (Ag)-based antimicrobials are promising to combat antibiotic resistant S. aureus , yet their molecular targets are largely elusive. Herein, we separate and identify 38 authentic Ag + -binding proteins in S. aureus at the whole-cell scale. We then capture the molecular snapshot on the dynamic action of Ag + against S. aureus and further validate that Ag + could inhibit a key target 6-phosphogluconate dehydrogenase through binding to catalytic His185 by X-ray crystallography. Significantly, the multi-target mode of action of Ag + (and nanosilver) endows its sustainable antimicrobial efficacy, leading to enhanced efficacy of conventional antibiotics and resensitization of MRSA to antibiotics. Our study resolves the long-standing question of the molecular targets of silver in S. aureus and offers insights into the sustainable bacterial susceptibility of silver, providing a potential approach for combating antimicrobial resistance." @default.
- W3172548148 created "2021-06-22" @default.
- W3172548148 creator A5002753875 @default.
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- W3172548148 date "2021-06-07" @default.
- W3172548148 modified "2023-10-15" @default.
- W3172548148 title "Multi-target mode of action of silver against Staphylococcus aureus endows it with capability to combat antibiotic resistance" @default.
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- W3172548148 doi "https://doi.org/10.1038/s41467-021-23659-y" @default.
- W3172548148 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8184742" @default.
- W3172548148 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34099682" @default.