Matches in SemOpenAlex for { <https://semopenalex.org/work/W3172576671> ?p ?o ?g. }
- W3172576671 abstract "Exercise likely has numerous benefits for brain and cognition. However, those benefits and their causes remain imprecisely defined. If the brain does benefit from exercise it does so primarily through cumulative brief, acute exposures over a lifetime. The Dementia Risk and Dynamic Response to Exercise (DYNAMIC) clinical trial seeks to characterize the acute exercise response in cerebral perfusion, and circulating neurotrophic factors in older adults with and without the apolipoprotein e4 genotype (APOE4), the strongest genetic predictor of sporadic, late onset Alzheimer's disease. DYNAMIC will enroll 60 older adults into a single moderate intensity bout of exercise intervention, measuring pre- and post-exercise cerebral blood flow (CBF) using arterial spin labeling, and neurotrophic factors. We expect that APOE4 carriers will have poor CBF regulation, i.e. slower return to baseline perfusion after exercise, and will demonstrate blunted neurotrophic response to exercise, with concentrations of neurotrophic factors positively correlating with CBF regulation. Preliminary findings on 7 older adults and 9 younger adults demonstrate that the experimental method can capture CBF and neurotrophic response over a time course. This methodology will provide important insight into acute exercise response and potential directions for clinical trial outcomes.ClinicalTrials.gov NCT04009629, Registered 05/07/2019." @default.
- W3172576671 created "2021-06-22" @default.
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- W3172576671 date "2021-06-17" @default.
- W3172576671 modified "2023-10-14" @default.
- W3172576671 title "A methodology for an acute exercise clinical trial called dementia risk and dynamic response to exercise" @default.
- W3172576671 cites W1438800491 @default.
- W3172576671 cites W1525745135 @default.
- W3172576671 cites W1535253686 @default.
- W3172576671 cites W1608895671 @default.
- W3172576671 cites W1914048043 @default.
- W3172576671 cites W1928978797 @default.
- W3172576671 cites W1954245799 @default.
- W3172576671 cites W1970632050 @default.
- W3172576671 cites W1971334793 @default.
- W3172576671 cites W1974381261 @default.
- W3172576671 cites W1979017394 @default.
- W3172576671 cites W1991495056 @default.
- W3172576671 cites W1991952617 @default.
- W3172576671 cites W1992403138 @default.
- W3172576671 cites W1995118675 @default.
- W3172576671 cites W1999522048 @default.
- W3172576671 cites W2012403948 @default.
- W3172576671 cites W2013253202 @default.
- W3172576671 cites W2017079501 @default.
- W3172576671 cites W2022089526 @default.
- W3172576671 cites W2022263664 @default.
- W3172576671 cites W2028021868 @default.
- W3172576671 cites W2031762899 @default.
- W3172576671 cites W2031795990 @default.
- W3172576671 cites W2044921939 @default.
- W3172576671 cites W2045085757 @default.
- W3172576671 cites W2052171331 @default.
- W3172576671 cites W2058957804 @default.
- W3172576671 cites W2063225300 @default.
- W3172576671 cites W2073513067 @default.
- W3172576671 cites W2079959894 @default.
- W3172576671 cites W2093274439 @default.
- W3172576671 cites W2093757589 @default.
- W3172576671 cites W2094887465 @default.
- W3172576671 cites W2096688252 @default.
- W3172576671 cites W2102672973 @default.
- W3172576671 cites W2109381172 @default.
- W3172576671 cites W2109527205 @default.
- W3172576671 cites W2110665915 @default.
- W3172576671 cites W2118799950 @default.
- W3172576671 cites W2129030266 @default.
- W3172576671 cites W2145944042 @default.
- W3172576671 cites W2146980963 @default.
- W3172576671 cites W2150177485 @default.
- W3172576671 cites W2153355885 @default.
- W3172576671 cites W2154320237 @default.
- W3172576671 cites W2158662933 @default.
- W3172576671 cites W2163871541 @default.
- W3172576671 cites W2164037272 @default.
- W3172576671 cites W2164133449 @default.
- W3172576671 cites W2166106170 @default.
- W3172576671 cites W2166949480 @default.
- W3172576671 cites W2167417288 @default.
- W3172576671 cites W2167897339 @default.
- W3172576671 cites W2275281596 @default.
- W3172576671 cites W2315327674 @default.
- W3172576671 cites W2334428983 @default.
- W3172576671 cites W2342723962 @default.
- W3172576671 cites W2432921129 @default.
- W3172576671 cites W2461788933 @default.
- W3172576671 cites W2464296914 @default.
- W3172576671 cites W2485975598 @default.
- W3172576671 cites W2592481273 @default.
- W3172576671 cites W2594290162 @default.
- W3172576671 cites W2602772966 @default.
- W3172576671 cites W2622229215 @default.
- W3172576671 cites W2729737290 @default.
- W3172576671 cites W2744855773 @default.
- W3172576671 cites W2746470689 @default.
- W3172576671 cites W2765855413 @default.
- W3172576671 cites W2771594778 @default.
- W3172576671 cites W2779580162 @default.
- W3172576671 cites W2944460862 @default.
- W3172576671 cites W2945893642 @default.
- W3172576671 cites W2970898057 @default.
- W3172576671 cites W3014251530 @default.
- W3172576671 cites W3029490310 @default.
- W3172576671 cites W3093710326 @default.
- W3172576671 cites W4241230192 @default.
- W3172576671 cites W4255732843 @default.
- W3172576671 cites W4294183730 @default.
- W3172576671 doi "https://doi.org/10.1038/s41598-021-92177-0" @default.
- W3172576671 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8211849" @default.