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- W3172623022 endingPage "592" @default.
- W3172623022 startingPage "561" @default.
- W3172623022 abstract "The rise of systems biology has ushered a new paradigm: the view of the cell as a system that processes environmental inputs to drive phenotypic outputs. Synthetic biology provides a complementary approach, allowing us to program cell behavior through the addition of synthetic genetic devices into the cellular processor. These devices, and the complex genetic circuits they compose, are engineered using a design-prototype-test cycle, allowing for predictable device performance to be achieved in a context-dependent manner. Within mammalian cells, context effects impact device performance at multiple scales, including the genetic, cellular, and extracellular levels. In order for synthetic genetic devices to achieve predictable behaviors, approaches to overcome context dependence are necessary. Here, we describe control systems approaches for achieving context-aware devices that are robust to context effects. We then consider cell fate programing as a case study to explore the potential impact of context-aware devices for regenerative medicine applications." @default.
- W3172623022 created "2021-06-22" @default.
- W3172623022 creator A5021591033 @default.
- W3172623022 creator A5036095256 @default.
- W3172623022 creator A5083965334 @default.
- W3172623022 creator A5090030865 @default.
- W3172623022 date "2021-06-01" @default.
- W3172623022 modified "2023-10-15" @default.
- W3172623022 title "Context-aware synthetic biology by controller design: Engineering the mammalian cell" @default.
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