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- W3172634669 abstract "Abstract Living organisms repeatedly encounter stressful events and apply various strategies to survive. Polyamines are omnipresent bioactive molecules with multiple functions. Their transient synthesis, inducible by numerous stressful stimuli, is termed the polyamine stress response. Animals developed evolutionary-conserved strategies to cope with stresses. The urea cycle is an ancient attribute that deals with ammonia excess in terrestrial species. Remarkably, most fish retain the urea cycle genes fully expressed during the early stages of development and silenced in adult animals. Environmental challenges instigate urea synthesis in fish despite substantial energetic costs, which poses a question of the urea cycle's evolutionary significance. Arginase plays a critical role in oxidative stress-dependent reactions being the final urea cycle' enzyme. Its unique subcellular localization, high inducibility, several regulation levels provide a supreme ability to control the polyamine synthesis rate. Of note, oxidative stress instigates the arginase-1 activity in mammals. Arginase is also dysregulated in aging organisms' brain and muscle tissues, indicating its role in the pathogenesis of age-associated diseases. We designed a study to investigate the levels of the urea cycle and polyamine synthesis-related enzymes in a fish model of acute hypoxia. We evidence synchronized elevation of arginase-2 and ornithine decarboxylase following oxidative stress in adult fish and aging animals that underlines the specific function of arginase-2 in fish. Moreover, we demonstrate oxidative stress-associated polyamine synthesis' induction and urea cycle' arrest in adult fish. The subcellular arginase localization found in the fish seems to correspond to its possible evolutionary roles." @default.
- W3172634669 created "2021-06-22" @default.
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- W3172634669 date "2021-06-10" @default.
- W3172634669 modified "2023-09-24" @default.
- W3172634669 title "Acute Hypoxia Elevates Arginase 2 and Induces Polyamine Stress Response in Zebrafish via Evolutionary-conserved Mechanism" @default.
- W3172634669 doi "https://doi.org/10.21203/rs.3.rs-595067/v1" @default.
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