FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3172664564> ?p ?o ?g. }

• W3172664564 endingPage "4924" @default.
• W3172664564 startingPage "4917" @default.
• W3172664564 abstract "Blood clots (90%) originate from the left atrial appendage (LAA) in non-valvular atrial fibrillation patients and are a major cause of embolic stroke. Long-term anticoagulation therapy has been used to prevent thrombus formation, but its use is limited in patients at a high risk for bleeding complications. Thus, left atrial appendage closure (LAAC) devices for LAA occlusion are well-established as an alternative to the anticoagulation therapy. However, the anticoagulation therapy is still required for at least 45 days post-implantation to bridge the time until complete LAA occlusion by neoendocardium coverage of the device. In this study, we applied an endothelium-mimicking nanomatrix to the LAAC device membrane for delivery of nitric oxide (NO) to enhance endothelialization, with the goal of possibly being able to reduce the duration of the anticoagulation therapy. The nanomatrix was uniformly coated on the LAAC device membranes and provided sustained release of NO for up to 1 month in vitro. In addition, the nanomatrix coating promoted endothelial cell proliferation and reduced platelet adhesion compared to the uncoated device membranes in vitro. The nanomatrix-coated and uncoated LAAC devices were then deployed in a canine LAA model for 22 days as a pilot study. All LAAC devices were not completely covered by neoendocardium 22 days post-implantation. However, histology image analysis showed that the nanomatrix-coated LAAC device had thicker neoendocardium coverage compared to the uncoated device. Therefore, our in vitro and in vivo results indicate that the nanomatrix coating has the potential to enhance endothelialization on the LAAC device membrane, which could improve patient outcomes by shortening the need for extended anticoagulation treatment." @default.
• W3172664564 created "2021-06-22" @default.
• W3172664564 creator A5013309524 @default.
• W3172664564 creator A5018101591 @default.
• W3172664564 creator A5022807246 @default.
• W3172664564 creator A5026338916 @default.
• W3172664564 creator A5051453414 @default.
• W3172664564 creator A5056475460 @default.
• W3172664564 creator A5061489035 @default.
• W3172664564 creator A5068359233 @default.
• W3172664564 creator A5079913623 @default.
• W3172664564 date "2021-06-01" @default.
• W3172664564 modified "2023-10-18" @default.
• W3172664564 title "Endothelium-Mimicking Nanomatrix Coating to Enhance Endothelialization after Left Atrial Appendage Closure Device Implantation" @default.
• W3172664564 cites W165111778 @default.
• W3172664564 cites W165952365 @default.
• W3172664564 cites W1842474705 @default.
• W3172664564 cites W1990076903 @default.
• W3172664564 cites W1990117605 @default.
• W3172664564 cites W1999238205 @default.
• W3172664564 cites W2012154384 @default.
• W3172664564 cites W2013483080 @default.
• W3172664564 cites W201608300 @default.
• W3172664564 cites W2020841720 @default.
• W3172664564 cites W2044927219 @default.
• W3172664564 cites W2053482681 @default.
• W3172664564 cites W2058987278 @default.
• W3172664564 cites W2064290602 @default.
• W3172664564 cites W2091490706 @default.
• W3172664564 cites W2096246254 @default.
• W3172664564 cites W2097854437 @default.
• W3172664564 cites W2101745268 @default.
• W3172664564 cites W2111395084 @default.
• W3172664564 cites W2132505348 @default.
• W3172664564 cites W2136224534 @default.
• W3172664564 cites W2136489990 @default.
• W3172664564 cites W2157942104 @default.
• W3172664564 cites W2162508946 @default.
• W3172664564 cites W2165753570 @default.
• W3172664564 cites W2169304723 @default.
• W3172664564 cites W2267941286 @default.
• W3172664564 cites W2287483321 @default.
• W3172664564 cites W2316501372 @default.
• W3172664564 cites W2344481617 @default.
• W3172664564 cites W2416585664 @default.
• W3172664564 cites W2417691030 @default.
• W3172664564 cites W2418636916 @default.
• W3172664564 cites W2769061399 @default.
• W3172664564 cites W2784146546 @default.
• W3172664564 cites W3006449451 @default.
• W3172664564 cites W3012264214 @default.
• W3172664564 cites W3013229569 @default.
• W3172664564 cites W3102646720 @default.
• W3172664564 cites W3118960961 @default.
• W3172664564 cites W4211191293 @default.
• W3172664564 cites W4292329040 @default.
• W3172664564 cites W596866713 @default.
• W3172664564 doi "https://doi.org/10.1021/acsabm.1c00202" @default.
• W3172664564 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35007040" @default.
• W3172664564 hasPublicationYear "2021" @default.
• W3172664564 type Work @default.
• W3172664564 sameAs 3172664564 @default.
• W3172664564 citedByCount "1" @default.
• W3172664564 countsByYear W31726645642023 @default.
• W3172664564 crossrefType "journal-article" @default.
• W3172664564 hasAuthorship W3172664564A5013309524 @default.
• W3172664564 hasAuthorship W3172664564A5018101591 @default.
• W3172664564 hasAuthorship W3172664564A5022807246 @default.
• W3172664564 hasAuthorship W3172664564A5026338916 @default.
• W3172664564 hasAuthorship W3172664564A5051453414 @default.
• W3172664564 hasAuthorship W3172664564A5056475460 @default.
• W3172664564 hasAuthorship W3172664564A5061489035 @default.
• W3172664564 hasAuthorship W3172664564A5068359233 @default.
• W3172664564 hasAuthorship W3172664564A5079913623 @default.
• W3172664564 hasBestOaLocation W31726645642 @default.
• W3172664564 hasConcept C126322002 @default.
• W3172664564 hasConcept C136229726 @default.
• W3172664564 hasConcept C164705383 @default.
• W3172664564 hasConcept C185592680 @default.
• W3172664564 hasConcept C192562407 @default.
• W3172664564 hasConcept C2776268601 @default.
• W3172664564 hasConcept C2776992346 @default.
• W3172664564 hasConcept C2779161974 @default.
• W3172664564 hasConcept C2781362458 @default.
• W3172664564 hasConcept C71924100 @default.
• W3172664564 hasConceptScore W3172664564C126322002 @default.
• W3172664564 hasConceptScore W3172664564C136229726 @default.
• W3172664564 hasConceptScore W3172664564C164705383 @default.
• W3172664564 hasConceptScore W3172664564C185592680 @default.
• W3172664564 hasConceptScore W3172664564C192562407 @default.
• W3172664564 hasConceptScore W3172664564C2776268601 @default.
• W3172664564 hasConceptScore W3172664564C2776992346 @default.
• W3172664564 hasConceptScore W3172664564C2779161974 @default.
• W3172664564 hasConceptScore W3172664564C2781362458 @default.
• W3172664564 hasConceptScore W3172664564C71924100 @default.
• W3172664564 hasFunder F4320337338 @default.
• W3172664564 hasFunder F4320337359 @default.
• W3172664564 hasIssue "6" @default.

• next