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- W3172668664 endingPage "6618" @default.
- W3172668664 startingPage "6618" @default.
- W3172668664 abstract "BODIPY dyes have recently attracted attention as potential photosensitizers. In this work, commercial and novel photosensitizers (PSs) based on BODIPY chromophores (haloBODIPYs and orthogonal dimers strategically designed with intense bands in the blue, green or red region of the visible spectra and high singlet oxygen production) were covalently linked to mesoporous silica nanoparticles (MSNs) further functionalized with PEG and folic acid (FA). MSNs approximately 50 nm in size with different functional groups were synthesized to allow multiple alternatives of PS-PEG-FA decoration of their external surface. Different combinations varying the type of PS (commercial Rose Bengal, Thionine and Chlorine e6 or custom-made BODIPY-based), the linkage design, and the length of PEG are detailed. All the nanosystems were physicochemically characterized (morphology, diameter, size distribution and PS loaded amount) and photophysically studied (absorption capacity, fluorescence efficiency, and singlet oxygen production) in suspension. For the most promising PS-PEG-FA silica nanoplatforms, the biocompatibility in dark conditions and the phototoxicity under suitable irradiation wavelengths (blue, green, or red) at regulated light doses (10–15 J/cm2) were compared with PSs free in solution in HeLa cells in vitro." @default.
- W3172668664 created "2021-06-22" @default.
- W3172668664 creator A5003103890 @default.
- W3172668664 creator A5008104839 @default.
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- W3172668664 creator A5024866992 @default.
- W3172668664 creator A5042996489 @default.
- W3172668664 creator A5046125392 @default.
- W3172668664 date "2021-06-21" @default.
- W3172668664 modified "2023-10-18" @default.
- W3172668664 title "Functionalization of Photosensitized Silica Nanoparticles for Advanced Photodynamic Therapy of Cancer" @default.
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