Matches in SemOpenAlex for { <https://semopenalex.org/work/W3172775101> ?p ?o ?g. }
- W3172775101 abstract "As a result of impressive increases in our knowledge of rodent and human immunology, the understanding of the pathophysiologic mechanisms underlying graft-versus-host disease (GVHD) has dramatically improved in the past 15 years. Despite improved knowledge, translation to clinical care has not proceeded rapidly, and results from experimental models have been inconsistent in their ability to predict the clinical utility of new therapeutic agents. In parallel, new tools in immunology have allowed in-depth analyses of the human system and have recently been applied in the field of clinical GVHD. Notwithstanding these advances, there is a relative paucity of mechanistic insights into human translational research, and this remains an area of high unmet need. Here we review selected recent advances in both preclinical experimental transplantation and translational human studies, including new insights into human immunology, the microbiome, and regenerative medicine. We focus on the fact that both approaches can interactively improve our understanding of both acute and chronic GVHD biology and open the door to improved therapeutics and successes." @default.
- W3172775101 created "2021-06-22" @default.
- W3172775101 creator A5012722789 @default.
- W3172775101 creator A5014705544 @default.
- W3172775101 creator A5027478389 @default.
- W3172775101 creator A5084803299 @default.
- W3172775101 date "2021-06-08" @default.
- W3172775101 modified "2023-10-17" @default.
- W3172775101 title "Insights from integrating clinical and preclinical studies advance understanding of graft-versus-host disease" @default.
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