Matches in SemOpenAlex for { <https://semopenalex.org/work/W3172810344> ?p ?o ?g. }
- W3172810344 endingPage "15" @default.
- W3172810344 startingPage "1" @default.
- W3172810344 abstract "Myocardial infarction (MI) is a devastating disease with high morbidity and mortality caused by the irreversible loss of functional cardiomyocytes and heart failure (HF) due to the restricted blood supply. Mesenchymal stem cells (MSCs) have been emerging as lead candidates to treat MI and subsequent HF mainly through secreting multitudinous factors of which exosomes act as the most effective constituent to boost the repair of heart function through carrying noncoding RNAs and proteins. Given the advantages of higher stability in the circulation, lower toxicity, and controllable transplantation dosage, exosomes have been described as a wonderful and promising cell-free treatment method in cardiovascular disease. Nowadays, MSC-derived exosomes have been proposed as a promising therapeutic approach to improve cardiac function and reverse heart remodeling. However, exosomes’ lack of modification cannot result in desired therapeutic effect. Hence, optimized exosomes can be developed via various engineering methods such as pharmacological compound preconditioned MSCs, genetically modified MSCs, or miRNA-loaded exosomes and peptide tagged exosomes to improve the targeting and therapeutic effects of exosomes. The biological characteristics, therapeutic potential, and optimizing strategy of exosomes will be described in our review." @default.
- W3172810344 created "2021-06-22" @default.
- W3172810344 creator A5021553057 @default.
- W3172810344 creator A5029598460 @default.
- W3172810344 creator A5040098991 @default.
- W3172810344 creator A5048238301 @default.
- W3172810344 creator A5058637832 @default.
- W3172810344 creator A5062620029 @default.
- W3172810344 creator A5080054083 @default.
- W3172810344 date "2021-06-01" @default.
- W3172810344 modified "2023-10-14" @default.
- W3172810344 title "The Application Potential and Advance of Mesenchymal Stem Cell-Derived Exosomes in Myocardial Infarction" @default.
- W3172810344 cites W1542448731 @default.
- W3172810344 cites W1549853423 @default.
- W3172810344 cites W1596481474 @default.
- W3172810344 cites W1834712221 @default.
- W3172810344 cites W1878908422 @default.
- W3172810344 cites W1886817675 @default.
- W3172810344 cites W1965913620 @default.
- W3172810344 cites W1968081342 @default.
- W3172810344 cites W1971218073 @default.
- W3172810344 cites W1976814389 @default.
- W3172810344 cites W1981571777 @default.
- W3172810344 cites W1983840318 @default.
- W3172810344 cites W1983970047 @default.
- W3172810344 cites W1984807833 @default.
- W3172810344 cites W1987885331 @default.
- W3172810344 cites W1990597414 @default.
- W3172810344 cites W1991865594 @default.
- W3172810344 cites W1994521618 @default.
- W3172810344 cites W1997044378 @default.
- W3172810344 cites W2001152899 @default.
- W3172810344 cites W2005777227 @default.
- W3172810344 cites W2007499410 @default.
- W3172810344 cites W2009485059 @default.
- W3172810344 cites W2009530133 @default.
- W3172810344 cites W2010746084 @default.
- W3172810344 cites W2012549032 @default.
- W3172810344 cites W2019917125 @default.
- W3172810344 cites W2041302930 @default.
- W3172810344 cites W2044432093 @default.
- W3172810344 cites W2046294034 @default.
- W3172810344 cites W2052344110 @default.
- W3172810344 cites W2060387475 @default.
- W3172810344 cites W2066426973 @default.
- W3172810344 cites W2078424563 @default.
- W3172810344 cites W2079156182 @default.
- W3172810344 cites W2089193076 @default.
- W3172810344 cites W2090335937 @default.
- W3172810344 cites W2098259366 @default.
- W3172810344 cites W2121354606 @default.
- W3172810344 cites W2124396531 @default.
- W3172810344 cites W2124925707 @default.
- W3172810344 cites W2126147950 @default.
- W3172810344 cites W2140928988 @default.
- W3172810344 cites W2170852633 @default.
- W3172810344 cites W2175410088 @default.
- W3172810344 cites W2191284640 @default.
- W3172810344 cites W2206480183 @default.
- W3172810344 cites W2207291742 @default.
- W3172810344 cites W2262985044 @default.
- W3172810344 cites W2341030489 @default.
- W3172810344 cites W2395885798 @default.
- W3172810344 cites W2403245572 @default.
- W3172810344 cites W2463806122 @default.
- W3172810344 cites W2497469513 @default.
- W3172810344 cites W2518635402 @default.
- W3172810344 cites W2522345229 @default.
- W3172810344 cites W2549520480 @default.
- W3172810344 cites W2558738866 @default.
- W3172810344 cites W2572212643 @default.
- W3172810344 cites W2581501925 @default.
- W3172810344 cites W2592901756 @default.
- W3172810344 cites W2607411382 @default.
- W3172810344 cites W2732667418 @default.
- W3172810344 cites W2745411898 @default.
- W3172810344 cites W2760275598 @default.
- W3172810344 cites W2765400988 @default.
- W3172810344 cites W2766582147 @default.
- W3172810344 cites W2770602573 @default.
- W3172810344 cites W2771701352 @default.
- W3172810344 cites W2778232195 @default.
- W3172810344 cites W2780401948 @default.
- W3172810344 cites W2788782622 @default.
- W3172810344 cites W2790141179 @default.
- W3172810344 cites W2794260489 @default.
- W3172810344 cites W2801899862 @default.
- W3172810344 cites W2802757650 @default.
- W3172810344 cites W2806153026 @default.
- W3172810344 cites W2806803654 @default.
- W3172810344 cites W2807572737 @default.
- W3172810344 cites W2808912161 @default.
- W3172810344 cites W2810630268 @default.
- W3172810344 cites W2890854352 @default.
- W3172810344 cites W2898378446 @default.
- W3172810344 cites W2903201035 @default.
- W3172810344 cites W2908967960 @default.
- W3172810344 cites W2912363132 @default.