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- W3172875306 abstract "Certain D-enantiomeric synthetic host defence peptides have demonstrated remarkable activity against bacterial biofilms. However, it remains unclear whether a potent L- form of a synthetic peptide will retain this potency when comprised of D- amino acids. Starting from a series of seven L-form peptides with activity against S. aureus biofilms, the D-enantiomeric and retro inverso (RI) forms were synthesized on peptide arrays and their biofilm inhibition activity was assessed against S. aureus and P. aeruginosa biofilms. Interestingly, the D- and RI- isoforms of the peptides exerted peptide specific activity profiles that were distinct from their L-isoforms. Two D- peptides were identified from these initial screens with strong antibiofilm activity against both bacteria while exhibiting low hemolytic activity towards red blood cells. These D-enantiomeric peptides, D-3006 and D-3007, were synthesized to high purity to confirm their capacity to affect biofilm growth. In both cases, the highly pure D-enantiomeric peptides inhibited biofilm growth against several bacterial species and they also eradicated preformed biofilms in vitro. Their antibiofilm effects were further evaluated in an organoid model of skin biofilm infection as well as a murine model of bacterial abscess infection, revealing potent antibiofilm activity and low toxicity in both cases. These results highlight the potential of D-enantiomeric peptides to be developed as potential therapeutic options to treat biofilm associated infections." @default.
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- W3172875306 date "2021-05-27" @default.
- W3172875306 modified "2023-09-28" @default.
- W3172875306 title "Identification of a D-enantiomeric Synthetic Host Defence Peptide with Antibiofilm Activity in vitro and in vivo" @default.
- W3172875306 hasPublicationYear "2021" @default.
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