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• W3172959 abstract "Alcoholic liver disease (ALD) is the major liver disease in the developed world and characterized by hepatic iron overload in ca. 50% of all patients. This iron overload is an independent factor of disease progression, hepatocellular carcinoma and it determines survival. Since simple phlebotomy does not allow the efficient removal of excess iron in ALD, a better understanding of the underlying mechanisms is urgently needed to identify novel targeted treatment strategies. This review summarizes the present knowledge on iron overload in patients with ALD. Although multiple sides of the cellular and systemic iron homeostasis may be affected during alcohol consumption, most studies have focused on potential hepatic causes. However, it should not be overlooked that more than 90% of the major iron pool, the hemoglobin-associated iron, is efficiently recycled within the human body and it is also strongly affected by alcohol. The few available studies suggest various molecular mechanisms that involve iron regulatory protein (IRP1), transferrin receptor 1 (TfR1), and the systemic iron master switch hepcidin, but not classical mutations of the HFE gene. Notably, reactive oxygen species (ROS), namely, hydrogen peroxide (H2O2), are powerful modulators of these iron-steering proteins. For instance, depending on the level, H2O2 may both strongly suppress and induce the expression of hepcidin that could partly explain the anemia and iron overload observed in these patients. More studies with appropriate ROS models such as the novel GOX/CAT system are required to unravel the mechanisms of iron overload in ALD to consequently identify molecular-targeted therapies in the future." @default.
• W3172959 created "2016-06-24" @default.
• W3172959 creator A5016582783 @default.
• W3172959 creator A5021062085 @default.
• W3172959 date "2014-11-10" @default.
• W3172959 modified "2023-10-01" @default.
• W3172959 title "The Role of Iron in Alcohol-Mediated Hepatocarcinogenesis" @default.
• W3172959 cites W1505596598 @default.
• W3172959 cites W1844349716 @default.
• W3172959 cites W1958309861 @default.
• W3172959 cites W1964051982 @default.
• W3172959 cites W1965385474 @default.
• W3172959 cites W1968603331 @default.
• W3172959 cites W1969296748 @default.
• W3172959 cites W1972242956 @default.
• W3172959 cites W1980287067 @default.
• W3172959 cites W1987171553 @default.
• W3172959 cites W1988150327 @default.
• W3172959 cites W1990040492 @default.
• W3172959 cites W1993133850 @default.
• W3172959 cites W1997734311 @default.
• W3172959 cites W1998351143 @default.
• W3172959 cites W1999166320 @default.
• W3172959 cites W1999814465 @default.
• W3172959 cites W1999956739 @default.
• W3172959 cites W2002605005 @default.
• W3172959 cites W2004283265 @default.
• W3172959 cites W2004583111 @default.
• W3172959 cites W2008376250 @default.
• W3172959 cites W2008564265 @default.
• W3172959 cites W2015258718 @default.
• W3172959 cites W2018411741 @default.
• W3172959 cites W2022274282 @default.
• W3172959 cites W2023981089 @default.
• W3172959 cites W2029071235 @default.
• W3172959 cites W2029080626 @default.
• W3172959 cites W2031466191 @default.
• W3172959 cites W2031547969 @default.
• W3172959 cites W2034450932 @default.
• W3172959 cites W2043523270 @default.
• W3172959 cites W2046188725 @default.
• W3172959 cites W2054250655 @default.
• W3172959 cites W2055729713 @default.
• W3172959 cites W2061900539 @default.
• W3172959 cites W2063836531 @default.
• W3172959 cites W2066497688 @default.
• W3172959 cites W2073271820 @default.
• W3172959 cites W2074761456 @default.
• W3172959 cites W2081840921 @default.
• W3172959 cites W2086246137 @default.
• W3172959 cites W2090165219 @default.
• W3172959 cites W2094748234 @default.
• W3172959 cites W2099465787 @default.
• W3172959 cites W2107072141 @default.
• W3172959 cites W2107704801 @default.
• W3172959 cites W2110118982 @default.
• W3172959 cites W2114015514 @default.
• W3172959 cites W2119148197 @default.
• W3172959 cites W2120359196 @default.
• W3172959 cites W2121798267 @default.
• W3172959 cites W2123200029 @default.
• W3172959 cites W2125065061 @default.
• W3172959 cites W2127473634 @default.
• W3172959 cites W2130235420 @default.
• W3172959 cites W2133753878 @default.
• W3172959 cites W2137014535 @default.
• W3172959 cites W2141751261 @default.
• W3172959 cites W2143154315 @default.
• W3172959 cites W2144494533 @default.
• W3172959 cites W2147230381 @default.
• W3172959 cites W2148499854 @default.
• W3172959 cites W2151876238 @default.
• W3172959 cites W2158115535 @default.
• W3172959 cites W2166050484 @default.
• W3172959 cites W2172908732 @default.
• W3172959 cites W2313992284 @default.
• W3172959 cites W2437218732 @default.
• W3172959 cites W4235352112 @default.
• W3172959 cites W4244093564 @default.
• W3172959 cites W4246537033 @default.
• W3172959 cites W86148309 @default.
• W3172959 doi "https://doi.org/10.1007/978-3-319-09614-8_6" @default.
• W3172959 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25427903" @default.
• W3172959 hasPublicationYear "2014" @default.
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