Matches in SemOpenAlex for { <https://semopenalex.org/work/W3173003579> ?p ?o ?g. }
- W3173003579 abstract "Our understanding of protective versus pathological immune responses to SARS-CoV-2, the virus that causes coronavirus disease 2019 (COVID-19), is limited by inadequate profiling of patients at the extremes of the disease severity spectrum. Here, we performed multi-omic single-cell immune profiling of 64 COVID-19 patients across the full range of disease severity, from outpatients with mild disease to fatal cases. Our transcriptomic, epigenomic, and proteomic analyses revealed widespread dysfunction of peripheral innate immunity in severe and fatal COVID-19, including prominent hyperactivation signatures in neutrophils and NK cells. We also identified chromatin accessibility changes at NF-κB binding sites within cytokine gene loci as a potential mechanism for the striking lack of pro-inflammatory cytokine production observed in monocytes in severe and fatal COVID-19. We further demonstrated that emergency myelopoiesis is a prominent feature of fatal COVID-19. Collectively, our results reveal disease severity–associated immune phenotypes in COVID-19 and identify pathogenesis-associated pathways that are potential targets for therapeutic intervention." @default.
- W3173003579 created "2021-06-22" @default.
- W3173003579 creator A5001775891 @default.
- W3173003579 creator A5003674456 @default.
- W3173003579 creator A5006749713 @default.
- W3173003579 creator A5008729380 @default.
- W3173003579 creator A5011918051 @default.
- W3173003579 creator A5014323653 @default.
- W3173003579 creator A5014958730 @default.
- W3173003579 creator A5015656765 @default.
- W3173003579 creator A5017140133 @default.
- W3173003579 creator A5020491178 @default.
- W3173003579 creator A5020565341 @default.
- W3173003579 creator A5021382133 @default.
- W3173003579 creator A5024617071 @default.
- W3173003579 creator A5026456130 @default.
- W3173003579 creator A5027307064 @default.
- W3173003579 creator A5027655714 @default.
- W3173003579 creator A5028760615 @default.
- W3173003579 creator A5029316595 @default.
- W3173003579 creator A5031492297 @default.
- W3173003579 creator A5034015016 @default.
- W3173003579 creator A5034194448 @default.
- W3173003579 creator A5034944160 @default.
- W3173003579 creator A5035178678 @default.
- W3173003579 creator A5038872432 @default.
- W3173003579 creator A5043901319 @default.
- W3173003579 creator A5044292612 @default.
- W3173003579 creator A5044643663 @default.
- W3173003579 creator A5046815252 @default.
- W3173003579 creator A5049127292 @default.
- W3173003579 creator A5054876585 @default.
- W3173003579 creator A5057124539 @default.
- W3173003579 creator A5057679568 @default.
- W3173003579 creator A5057717220 @default.
- W3173003579 creator A5058402194 @default.
- W3173003579 creator A5060970267 @default.
- W3173003579 creator A5061960323 @default.
- W3173003579 creator A5064975456 @default.
- W3173003579 creator A5066092294 @default.
- W3173003579 creator A5067871955 @default.
- W3173003579 creator A5068243893 @default.
- W3173003579 creator A5068822395 @default.
- W3173003579 creator A5070002999 @default.
- W3173003579 creator A5072556276 @default.
- W3173003579 creator A5072742167 @default.
- W3173003579 creator A5075216970 @default.
- W3173003579 creator A5075711252 @default.
- W3173003579 creator A5078223903 @default.
- W3173003579 creator A5079493144 @default.
- W3173003579 creator A5079729554 @default.
- W3173003579 creator A5080080229 @default.
- W3173003579 creator A5080722924 @default.
- W3173003579 creator A5083604044 @default.
- W3173003579 creator A5085442010 @default.
- W3173003579 creator A5086746858 @default.
- W3173003579 creator A5086888258 @default.
- W3173003579 creator A5088144945 @default.
- W3173003579 creator A5088207875 @default.
- W3173003579 creator A5090888026 @default.
- W3173003579 date "2021-06-15" @default.
- W3173003579 modified "2023-10-18" @default.
- W3173003579 title "Multi-omic profiling reveals widespread dysregulation of innate immunity and hematopoiesis in COVID-19" @default.
- W3173003579 cites W1517394132 @default.
- W3173003579 cites W1863751964 @default.
- W3173003579 cites W1904705252 @default.
- W3173003579 cites W1950981769 @default.
- W3173003579 cites W1966586109 @default.
- W3173003579 cites W1967114867 @default.
- W3173003579 cites W1970170720 @default.
- W3173003579 cites W1975312325 @default.
- W3173003579 cites W1993792708 @default.
- W3173003579 cites W1994656760 @default.
- W3173003579 cites W1998704756 @default.
- W3173003579 cites W2006977385 @default.
- W3173003579 cites W2007149178 @default.
- W3173003579 cites W2038426170 @default.
- W3173003579 cites W2061817584 @default.
- W3173003579 cites W2062183332 @default.
- W3173003579 cites W2064681544 @default.
- W3173003579 cites W2075901113 @default.
- W3173003579 cites W2083420798 @default.
- W3173003579 cites W2086542713 @default.
- W3173003579 cites W2090602346 @default.
- W3173003579 cites W2105357365 @default.
- W3173003579 cites W2107281049 @default.
- W3173003579 cites W2116830437 @default.
- W3173003579 cites W2125631056 @default.
- W3173003579 cites W2133562017 @default.
- W3173003579 cites W2135849676 @default.
- W3173003579 cites W2135919238 @default.
- W3173003579 cites W2151451117 @default.
- W3173003579 cites W2158924104 @default.
- W3173003579 cites W2161418196 @default.
- W3173003579 cites W2169456326 @default.
- W3173003579 cites W2200350105 @default.
- W3173003579 cites W2218326748 @default.
- W3173003579 cites W2271189918 @default.
- W3173003579 cites W2283124896 @default.
- W3173003579 cites W2481029670 @default.