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• W3173009826 abstract "In 2020, SARS-CoV-2 spread across the United States (U.S.) in three phases distinguished by peaks in the numbers of infections and shifting geographical distribution. We investigated the viral genetic diversity in each phase using sequences publicly available prior to December 15 th , 2020, when vaccination was initiated in the U.S. In Phase 1 (winter/spring), sequences were already dominated by the D614G Spike mutation and by Phase 3 (fall), genetic diversity of the viral population had tripled and at least 54 new amino acid changes had emerged at frequencies above 5%, several of which were within known antibody epitopes. These findings highlight the need to track the evolution of SARS-CoV-2 variants in the U.S. to ensure continued efficacy of vaccines and antiviral treatments.SARS-CoV-2 genetic diversity in the U.S. increased 3-fold in 2020 and 54 emergent nonsynonymous mutations were detected." @default.
• W3173009826 created "2021-06-22" @default.
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• W3173009826 date "2021-06-04" @default.
• W3173009826 modified "2023-09-26" @default.
• W3173009826 title "2020 SARS-CoV-2 diversification in the United States: Establishing a pre-vaccination baseline" @default.
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• W3173009826 doi "https://doi.org/10.1101/2021.06.01.21258185" @default.
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