Matches in SemOpenAlex for { <https://semopenalex.org/work/W3173010993> ?p ?o ?g. }
- W3173010993 endingPage "489" @default.
- W3173010993 startingPage "480" @default.
- W3173010993 abstract "Abstract Trametes lactinea mycelia polysaccharides (TLMPS) have a wide range of bioactivities. The potential mechanisms of action of TLMPS against acute alcohol-induced liver injury in vivo were investigated by analyzing the physical and chemical properties of TLMPS and its protective effects on a mouse model of alcoholic liver injury. TLMPS protected the liver against alcohol-induced injury, as evidenced by the reduced alcohol-induced elevation of the liver index, serum biochemical indices, and maintenance of hepatic morphology. Potential mechanisms were analyzed using transcriptome and metabolome analyses. The transcriptome data revealed the involvement of many differentially expressed genes in chemical carcinogenesis, drug metabolism, and metabolism of xenobiotics by cytochrome P450. The metabolome analysis revealed that TLMPS significantly regulated specific metabolites in the liver, including organic acids, lipids, nucleosides, and organic oxygen compounds. KEGG enrichment analysis revealed the significant involvement of different metabolites in choline metabolism, ATP-binding cassette transporters, and glycerophospholipid metabolism. Assessment of the changes in gene expression and metabolites revealed the significantly different expression of several genes encoding key enzymes and metabolites in choline metabolism pathway. The collective findings confirmed that choline metabolism plays an important role in the protective effects of TLMPS against acute alcoholic liver injury." @default.
- W3173010993 created "2021-06-22" @default.
- W3173010993 creator A5003256823 @default.
- W3173010993 creator A5033845983 @default.
- W3173010993 creator A5044483524 @default.
- W3173010993 creator A5051916399 @default.
- W3173010993 creator A5053638096 @default.
- W3173010993 creator A5056579164 @default.
- W3173010993 date "2021-07-01" @default.
- W3173010993 modified "2023-09-27" @default.
- W3173010993 title "The protective effect and crucial biological pathways analysis of Trametes lactinea mycelium polysaccharides on acute alcoholic liver injury in mice based on transcriptomics and metabonomics" @default.
- W3173010993 cites W1569473466 @default.
- W3173010993 cites W1965120990 @default.
- W3173010993 cites W1968834637 @default.
- W3173010993 cites W1983183210 @default.
- W3173010993 cites W1991527839 @default.
- W3173010993 cites W2000487584 @default.
- W3173010993 cites W2000599835 @default.
- W3173010993 cites W2006759718 @default.
- W3173010993 cites W2011886830 @default.
- W3173010993 cites W2015524702 @default.
- W3173010993 cites W2016341284 @default.
- W3173010993 cites W2018173167 @default.
- W3173010993 cites W2031018138 @default.
- W3173010993 cites W2054716478 @default.
- W3173010993 cites W2058791488 @default.
- W3173010993 cites W2060366963 @default.
- W3173010993 cites W2072029917 @default.
- W3173010993 cites W2074085264 @default.
- W3173010993 cites W2076870635 @default.
- W3173010993 cites W2128162367 @default.
- W3173010993 cites W2146574066 @default.
- W3173010993 cites W2155410757 @default.
- W3173010993 cites W2155602863 @default.
- W3173010993 cites W2234785566 @default.
- W3173010993 cites W2274415524 @default.
- W3173010993 cites W2318751202 @default.
- W3173010993 cites W2510875395 @default.
- W3173010993 cites W2606042779 @default.
- W3173010993 cites W2626309344 @default.
- W3173010993 cites W2734415540 @default.
- W3173010993 cites W2735682026 @default.
- W3173010993 cites W2782652436 @default.
- W3173010993 cites W2796949429 @default.
- W3173010993 cites W2799926029 @default.
- W3173010993 cites W2803664483 @default.
- W3173010993 cites W2890288728 @default.
- W3173010993 cites W2913726145 @default.
- W3173010993 cites W2914329514 @default.
- W3173010993 cites W2914358904 @default.
- W3173010993 cites W2941275711 @default.
- W3173010993 cites W2941950409 @default.
- W3173010993 cites W2980161313 @default.
- W3173010993 cites W4293247451 @default.
- W3173010993 doi "https://doi.org/10.1016/j.fshw.2021.04.010" @default.
- W3173010993 hasPublicationYear "2021" @default.
- W3173010993 type Work @default.
- W3173010993 sameAs 3173010993 @default.
- W3173010993 citedByCount "4" @default.
- W3173010993 countsByYear W31730109932022 @default.
- W3173010993 countsByYear W31730109932023 @default.
- W3173010993 crossrefType "journal-article" @default.
- W3173010993 hasAuthorship W3173010993A5003256823 @default.
- W3173010993 hasAuthorship W3173010993A5033845983 @default.
- W3173010993 hasAuthorship W3173010993A5044483524 @default.
- W3173010993 hasAuthorship W3173010993A5051916399 @default.
- W3173010993 hasAuthorship W3173010993A5053638096 @default.
- W3173010993 hasAuthorship W3173010993A5056579164 @default.
- W3173010993 hasBestOaLocation W31730109931 @default.
- W3173010993 hasConcept C100817775 @default.
- W3173010993 hasConcept C104317684 @default.
- W3173010993 hasConcept C133479454 @default.
- W3173010993 hasConcept C150194340 @default.
- W3173010993 hasConcept C162317418 @default.
- W3173010993 hasConcept C185592680 @default.
- W3173010993 hasConcept C2776637226 @default.
- W3173010993 hasConcept C55493867 @default.
- W3173010993 hasConcept C59822182 @default.
- W3173010993 hasConcept C86803240 @default.
- W3173010993 hasConcept C98274493 @default.
- W3173010993 hasConceptScore W3173010993C100817775 @default.
- W3173010993 hasConceptScore W3173010993C104317684 @default.
- W3173010993 hasConceptScore W3173010993C133479454 @default.
- W3173010993 hasConceptScore W3173010993C150194340 @default.
- W3173010993 hasConceptScore W3173010993C162317418 @default.
- W3173010993 hasConceptScore W3173010993C185592680 @default.
- W3173010993 hasConceptScore W3173010993C2776637226 @default.
- W3173010993 hasConceptScore W3173010993C55493867 @default.
- W3173010993 hasConceptScore W3173010993C59822182 @default.
- W3173010993 hasConceptScore W3173010993C86803240 @default.
- W3173010993 hasConceptScore W3173010993C98274493 @default.
- W3173010993 hasIssue "4" @default.
- W3173010993 hasLocation W31730109931 @default.
- W3173010993 hasOpenAccess W3173010993 @default.
- W3173010993 hasPrimaryLocation W31730109931 @default.
- W3173010993 hasRelatedWork W1574685304 @default.
- W3173010993 hasRelatedWork W2035403959 @default.
- W3173010993 hasRelatedWork W2382669309 @default.