Matches in SemOpenAlex for { <https://semopenalex.org/work/W3173077891> ?p ?o ?g. }
Showing items 1 to 67 of
67
with 100 items per page.
- W3173077891 endingPage "170" @default.
- W3173077891 startingPage "166" @default.
- W3173077891 abstract "Introduction: Teduglutide is a glucagon-like peptide 2 (GLP-2) analogue that has been approved for the treatment of patients with Short bowel syndrome (SBS) who are stable after a period of intestinal adaptation after surgery. Teduglutide increases villus height and crypt depth in the small bowel mucosa, promoting nutritional absorption and independence from parenteral support (PS). The present report aims to describe our experience with the use of teduglutide in adult patients with SBS in one single center. Method: We performed a retrospective and observational study on adult SBS patients who received teduglutide at our center from January 2018 to March 2020 with a follow-up of at least 12 weeks. To assess the effectiveness of teduglutide, the change in parenteral nutrition (PN) requirements was analyzed including a reduction in PN volume and/or PN days. The response to treatment with teduglutide was assessed at weeks 12, 24, 36 and at the end of the study. In addition, side effects were evaluated. Results: Four patients in all were treated with teduglutide. All the patients were dependent on parenteral nutrition five days per week. The treatment period with teduglutide until the end of the study ranged from 16 to 72 weeks in the patient series. All patients achieved ≥20% reduction in weekly PS volume and at least one day reduction of NP before week 24 of treatment. At the end of the study only two of the four patients continued with teduglutide with a treatment duration of 72 weeks. One patient maintained the enteral autonomy achieved from week 20 with teduglutide with subsequent removal of the central catheter. And the other patient had a decrease in the number of PN per week from five to two days from week 36. The adverse effects observed in the patient series were edema and effects related to the stoma. Conclusions: Teduglutide was effective and safe for promoting a decrease in parenteral support in two of our four patients. However, careful monitoring and an individualized patient management plan are necessary to obtain efficient results" @default.
- W3173077891 created "2021-06-22" @default.
- W3173077891 creator A5003925341 @default.
- W3173077891 creator A5010694400 @default.
- W3173077891 date "2020-01-01" @default.
- W3173077891 modified "2023-09-26" @default.
- W3173077891 title "Teduglutide in adult patients with short bowel syndrome" @default.
- W3173077891 hasPublicationYear "2020" @default.
- W3173077891 type Work @default.
- W3173077891 sameAs 3173077891 @default.
- W3173077891 citedByCount "0" @default.
- W3173077891 crossrefType "journal-article" @default.
- W3173077891 hasAuthorship W3173077891A5003925341 @default.
- W3173077891 hasAuthorship W3173077891A5010694400 @default.
- W3173077891 hasConcept C126322002 @default.
- W3173077891 hasConcept C141071460 @default.
- W3173077891 hasConcept C185592680 @default.
- W3173077891 hasConcept C2779281246 @default.
- W3173077891 hasConcept C2779820108 @default.
- W3173077891 hasConcept C2781219945 @default.
- W3173077891 hasConcept C44315111 @default.
- W3173077891 hasConcept C55493867 @default.
- W3173077891 hasConcept C71924100 @default.
- W3173077891 hasConcept C78722104 @default.
- W3173077891 hasConcept C90924648 @default.
- W3173077891 hasConceptScore W3173077891C126322002 @default.
- W3173077891 hasConceptScore W3173077891C141071460 @default.
- W3173077891 hasConceptScore W3173077891C185592680 @default.
- W3173077891 hasConceptScore W3173077891C2779281246 @default.
- W3173077891 hasConceptScore W3173077891C2779820108 @default.
- W3173077891 hasConceptScore W3173077891C2781219945 @default.
- W3173077891 hasConceptScore W3173077891C44315111 @default.
- W3173077891 hasConceptScore W3173077891C55493867 @default.
- W3173077891 hasConceptScore W3173077891C71924100 @default.
- W3173077891 hasConceptScore W3173077891C78722104 @default.
- W3173077891 hasConceptScore W3173077891C90924648 @default.
- W3173077891 hasIssue "3" @default.
- W3173077891 hasLocation W31730778911 @default.
- W3173077891 hasOpenAccess W3173077891 @default.
- W3173077891 hasPrimaryLocation W31730778911 @default.
- W3173077891 hasRelatedWork W2054210372 @default.
- W3173077891 hasRelatedWork W2078645587 @default.
- W3173077891 hasRelatedWork W2085752806 @default.
- W3173077891 hasRelatedWork W2097401734 @default.
- W3173077891 hasRelatedWork W2552934799 @default.
- W3173077891 hasRelatedWork W2588064444 @default.
- W3173077891 hasRelatedWork W2755273782 @default.
- W3173077891 hasRelatedWork W2770016679 @default.
- W3173077891 hasRelatedWork W2794536454 @default.
- W3173077891 hasRelatedWork W2886919829 @default.
- W3173077891 hasRelatedWork W2911828422 @default.
- W3173077891 hasRelatedWork W2912664169 @default.
- W3173077891 hasRelatedWork W2969856653 @default.
- W3173077891 hasRelatedWork W2972553335 @default.
- W3173077891 hasRelatedWork W2981573645 @default.
- W3173077891 hasRelatedWork W2982229977 @default.
- W3173077891 hasRelatedWork W2997122857 @default.
- W3173077891 hasRelatedWork W3202638626 @default.
- W3173077891 hasRelatedWork W3209963414 @default.
- W3173077891 hasRelatedWork W3111746121 @default.
- W3173077891 hasVolume "22" @default.
- W3173077891 isParatext "false" @default.
- W3173077891 isRetracted "false" @default.
- W3173077891 magId "3173077891" @default.
- W3173077891 workType "article" @default.