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• W3173081092 abstract "Impact related traumatic brain injury (TBI) commonly influences high-risk populations such as contact sports athletes and combat soldiers. Recovery results in mild to severe loss of motor and cognitive function. Prophylactic protection to enhance resilience and improve the rate and extent of recovery by nutrient supplementation is currently limited. Astaxanthin is a natural xantophyll carotenoid supplement which readily crosses the blood brain barrier (BBB) and was previously shown to improve recovery in a brain ischemia-reperfusion model when administered post injury. The study objective was to examine the effects of Astaxanthin pre-supplementation on the motor and cognitive aspects of recovery from a closed head injury (CHI) model in mice. Methods male sabra mice were treated with Astaxanthin 100 mg/Kg per day in olive oil by gavage (XO), or olive oil (O) or in pellet form as 1% Astaxanthin in animal food by free eating (X) for 2 weeks, exposed to a CHI model, and followed over a one month recovery period. Motor skills were assessed using the neurological severity score (NSS) at 1, 24, 48, and 72 hours and weekly post injury. Cognitive skills were assessed using the Open filed, and Y-Maze tests on days 2 and 29 post injury, and the novel object recognition (ORT) test on days 3 and 30 post injury. Ethics: all animal experiments were approved by the Hebrew University authority for biological and biomedical models ethical review board (registration numbers: MD-13-13734-4 & MD-16-14842-4). Results NSS scores revealed a significant improvement in motor skills recovery (ΔNSS=1.25±0.16 vs. 0.5±0.27 in XO vs. O, respectively, p=0.001), which began on week 2 and lasted to 4 w. Additional cognitive improvement was demonstrated in the Y-maze on Day 29: 44.57±3.22% vs. 36.46±1.95% of exploration time spent in the novel arm for XO vs. O, respectively, p=0.03). The results of the open field and ORT tests did not significantly differ between groups. When Astaxanthin supplementation was administered in pellet form (X), a considerably smaller influence was observed in the NSS compared to XO, while cognition (open field, Y-Maze, ORT) remained unaffected. Post injury X supplementation with or without pre supplementation did not improve results. Conclusion Results suggest an advantage to XO over X and O in motor and cognitive skills recovery. The results of the effect of XO on NSS and on cognitive function, versus the lack of similar motor and cognitive effects with X, suggest a contribution of the combined XO administration to motor and cognitive parameters and warrants further work to elucidate its mechanism as well as the effects of post injury XO supplementation. Support or Funding Information This work was funded by the IDF medical corps research authority This abstract is from the Experimental Biology 2018 Meeting. There is no full text article associated with this abstract published in The FASEB Journal." @default.
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• W3173081092 date "2018-04-01" @default.
• W3173081092 modified "2023-09-25" @default.
• W3173081092 title "Astaxanthin and Olive Oil Pretreatment Improves Recovery of Motor and Cognitive Skills in a Closed Head Injury TBI Model in Male Sabra Mice" @default.
• W3173081092 doi "https://doi.org/10.1096/fasebj.2018.32.1_supplement.877.1" @default.
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