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- W3173108234 abstract "Abstract We describe MIP-1 and MIP-2, novel paralogous C. elegans germ granule components that interact with the intrinsically disordered MEG-3 protein. These proteins promote P granule condensation, form granules independently of MEG-3 in the postembryonic germ line, and balance each other in regulating P granule growth and localization. MIP-1 and MIP-2 each contain two LOTUS domains and intrinsically disordered regions and form homo- and heterodimers. They bind and anchor the Vasa homolog GLH-1 within P granules and are jointly required for coalescence of MEG-3, GLH-1, and PGL proteins. Animals lacking MIP-1 and MIP-2 show temperature-sensitive embryonic lethality, sterility, and mortal germ lines. Germline phenotypes include defects in stem cell self-renewal, meiotic progression, and gamete differentiation. We propose that these proteins serve as scaffolds and organizing centers for ribonucleoprotein networks within P granules that help recruit and balance essential RNA processing machinery to regulate key developmental transitions in the germ line." @default.
- W3173108234 created "2021-06-22" @default.
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- W3173108234 date "2021-06-17" @default.
- W3173108234 modified "2023-10-14" @default.
- W3173108234 title "Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules" @default.
- W3173108234 cites W153460014 @default.
- W3173108234 cites W1585010992 @default.
- W3173108234 cites W1623015948 @default.
- W3173108234 cites W1903792504 @default.
- W3173108234 cites W1912455695 @default.
- W3173108234 cites W1921244251 @default.
- W3173108234 cites W1946560809 @default.
- W3173108234 cites W1965717293 @default.
- W3173108234 cites W1966708458 @default.
- W3173108234 cites W1968943425 @default.
- W3173108234 cites W1975350101 @default.
- W3173108234 cites W1978942137 @default.
- W3173108234 cites W1981264193 @default.
- W3173108234 cites W1986638937 @default.
- W3173108234 cites W1997987499 @default.
- W3173108234 cites W2001573278 @default.
- W3173108234 cites W2003236418 @default.
- W3173108234 cites W2013163897 @default.
- W3173108234 cites W2028839214 @default.
- W3173108234 cites W2031361194 @default.
- W3173108234 cites W2036321220 @default.
- W3173108234 cites W2037373597 @default.
- W3173108234 cites W2039885485 @default.
- W3173108234 cites W2051275283 @default.
- W3173108234 cites W2054352933 @default.
- W3173108234 cites W2059016392 @default.
- W3173108234 cites W2062289554 @default.
- W3173108234 cites W2077502289 @default.
- W3173108234 cites W2077650948 @default.
- W3173108234 cites W2080752012 @default.
- W3173108234 cites W2087895896 @default.
- W3173108234 cites W2089759992 @default.
- W3173108234 cites W2098085839 @default.
- W3173108234 cites W2098745876 @default.
- W3173108234 cites W2103006829 @default.
- W3173108234 cites W2103141445 @default.
- W3173108234 cites W2104873074 @default.
- W3173108234 cites W2111705021 @default.
- W3173108234 cites W2120686657 @default.
- W3173108234 cites W2137136678 @default.
- W3173108234 cites W2139066576 @default.
- W3173108234 cites W2142881677 @default.
- W3173108234 cites W2145561024 @default.
- W3173108234 cites W2150852081 @default.
- W3173108234 cites W2154740350 @default.
- W3173108234 cites W2155443196 @default.
- W3173108234 cites W2156957026 @default.
- W3173108234 cites W2157795344 @default.
- W3173108234 cites W2158714788 @default.
- W3173108234 cites W2159565935 @default.
- W3173108234 cites W2162396952 @default.
- W3173108234 cites W2163292043 @default.
- W3173108234 cites W2168639701 @default.
- W3173108234 cites W2170776626 @default.
- W3173108234 cites W2276471287 @default.
- W3173108234 cites W2284985228 @default.
- W3173108234 cites W2306536993 @default.
- W3173108234 cites W2342838938 @default.
- W3173108234 cites W2400072956 @default.
- W3173108234 cites W2463195069 @default.
- W3173108234 cites W2517195794 @default.
- W3173108234 cites W2590568317 @default.
- W3173108234 cites W2594424912 @default.
- W3173108234 cites W2605356232 @default.
- W3173108234 cites W2612797603 @default.
- W3173108234 cites W2617878309 @default.
- W3173108234 cites W2619990190 @default.
- W3173108234 cites W2625742743 @default.
- W3173108234 cites W2739261764 @default.
- W3173108234 cites W2756821926 @default.
- W3173108234 cites W2788409251 @default.
- W3173108234 cites W2792610706 @default.
- W3173108234 cites W2810246680 @default.
- W3173108234 cites W2886592312 @default.
- W3173108234 cites W2887353309 @default.
- W3173108234 cites W2890778381 @default.
- W3173108234 cites W2891283475 @default.
- W3173108234 cites W2893635239 @default.
- W3173108234 cites W2896320922 @default.
- W3173108234 cites W2903023652 @default.
- W3173108234 cites W2911861738 @default.