FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3173122987> ?p ?o ?g. }

• W3173122987 endingPage "6296" @default.
• W3173122987 startingPage "6296" @default.
• W3173122987 abstract "We investigated the role of nuclear factor of activated T cells 5 (NFAT5) under hyperosmotic conditions in human lens epithelial cells (HLECs). Hyperosmotic stress decreased the viability of human lens epithelial B-3 cells and significantly increased NFAT5 expression. Hyperosmotic stress-induced cell death occurred to a greater extent in NFAT5-knockout (KO) cells than in NFAT5 wild-type (NFAT5 WT) cells. Bcl-2 and Bcl-xl expression was down-regulated in NFAT5 WT cells and NFAT5 KO cells under hyperosmotic stress. Pre-treatment with a necroptosis inhibitor (necrostatin-1) significantly blocked hyperosmotic stress-induced death of NFAT5 KO cells, but not of NFAT5 WT cells. The phosphorylation levels of receptor-interacting protein kinase 1 (RIP1) and RIP3, which indicate the occurrence of necroptosis, were up-regulated in NFAT5 KO cells, suggesting that death of these cells is predominantly related to the necroptosis pathway. This finding is the first to report that necroptosis occurs when lens epithelial cells are exposed to hyperosmolar conditions, and that NFAT5 is involved in this process." @default.
• W3173122987 created "2021-06-22" @default.
• W3173122987 creator A5007296396 @default.
• W3173122987 creator A5014860906 @default.
• W3173122987 creator A5045663899 @default.
• W3173122987 creator A5058074460 @default.
• W3173122987 creator A5073469497 @default.
• W3173122987 creator A5089196867 @default.
• W3173122987 creator A5091901890 @default.
• W3173122987 date "2021-06-11" @default.
• W3173122987 modified "2023-09-27" @default.
• W3173122987 title "The Role of Nuclear Factor of Activated T Cells 5 in Hyperosmotic Stress-Exposed Human Lens Epithelial Cells" @default.
• W3173122987 cites W1898128059 @default.
• W3173122987 cites W1972241850 @default.
• W3173122987 cites W1981201913 @default.
• W3173122987 cites W1983908748 @default.
• W3173122987 cites W1990680026 @default.
• W3173122987 cites W1997601120 @default.
• W3173122987 cites W2012983777 @default.
• W3173122987 cites W2015494251 @default.
• W3173122987 cites W2015717266 @default.
• W3173122987 cites W2016497346 @default.
• W3173122987 cites W2016906437 @default.
• W3173122987 cites W2018468745 @default.
• W3173122987 cites W2019968039 @default.
• W3173122987 cites W2022000712 @default.
• W3173122987 cites W2025699489 @default.
• W3173122987 cites W2049778031 @default.
• W3173122987 cites W2053156125 @default.
• W3173122987 cites W2054246547 @default.
• W3173122987 cites W2054670584 @default.
• W3173122987 cites W2055038354 @default.
• W3173122987 cites W2071689641 @default.
• W3173122987 cites W2087232320 @default.
• W3173122987 cites W2096981766 @default.
• W3173122987 cites W2103093968 @default.
• W3173122987 cites W2104613854 @default.
• W3173122987 cites W2108047477 @default.
• W3173122987 cites W2109346042 @default.
• W3173122987 cites W2118592842 @default.
• W3173122987 cites W2119897280 @default.
• W3173122987 cites W2135568172 @default.
• W3173122987 cites W2139552156 @default.
• W3173122987 cites W2156462473 @default.
• W3173122987 cites W2159679709 @default.
• W3173122987 cites W2165424984 @default.
• W3173122987 cites W2313952020 @default.
• W3173122987 cites W2341780617 @default.
• W3173122987 cites W2990320007 @default.
• W3173122987 cites W2998893148 @default.
• W3173122987 cites W3107859769 @default.
• W3173122987 doi "https://doi.org/10.3390/ijms22126296" @default.
• W3173122987 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8230750" @default.
• W3173122987 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34208226" @default.
• W3173122987 hasPublicationYear "2021" @default.
• W3173122987 type Work @default.
• W3173122987 sameAs 3173122987 @default.
• W3173122987 citedByCount "3" @default.
• W3173122987 countsByYear W31731229872022 @default.
• W3173122987 countsByYear W31731229872023 @default.
• W3173122987 crossrefType "journal-article" @default.
• W3173122987 hasAuthorship W3173122987A5007296396 @default.
• W3173122987 hasAuthorship W3173122987A5014860906 @default.
• W3173122987 hasAuthorship W3173122987A5045663899 @default.
• W3173122987 hasAuthorship W3173122987A5058074460 @default.
• W3173122987 hasAuthorship W3173122987A5073469497 @default.
• W3173122987 hasAuthorship W3173122987A5089196867 @default.
• W3173122987 hasAuthorship W3173122987A5091901890 @default.
• W3173122987 hasBestOaLocation W31731229871 @default.
• W3173122987 hasConcept C11960822 @default.
• W3173122987 hasConcept C129900496 @default.
• W3173122987 hasConcept C153911025 @default.
• W3173122987 hasConcept C184235292 @default.
• W3173122987 hasConcept C185592680 @default.
• W3173122987 hasConcept C190283241 @default.
• W3173122987 hasConcept C31573885 @default.
• W3173122987 hasConcept C55493867 @default.
• W3173122987 hasConcept C86803240 @default.
• W3173122987 hasConcept C94030615 @default.
• W3173122987 hasConcept C95444343 @default.
• W3173122987 hasConceptScore W3173122987C11960822 @default.
• W3173122987 hasConceptScore W3173122987C129900496 @default.
• W3173122987 hasConceptScore W3173122987C153911025 @default.
• W3173122987 hasConceptScore W3173122987C184235292 @default.
• W3173122987 hasConceptScore W3173122987C185592680 @default.
• W3173122987 hasConceptScore W3173122987C190283241 @default.
• W3173122987 hasConceptScore W3173122987C31573885 @default.
• W3173122987 hasConceptScore W3173122987C55493867 @default.
• W3173122987 hasConceptScore W3173122987C86803240 @default.
• W3173122987 hasConceptScore W3173122987C94030615 @default.
• W3173122987 hasConceptScore W3173122987C95444343 @default.
• W3173122987 hasIssue "12" @default.
• W3173122987 hasLocation W31731229871 @default.
• W3173122987 hasLocation W31731229872 @default.
• W3173122987 hasLocation W31731229873 @default.
• W3173122987 hasOpenAccess W3173122987 @default.
• W3173122987 hasPrimaryLocation W31731229871 @default.
• W3173122987 hasRelatedWork W1988779395 @default.

• next