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- W3173125984 endingPage "1081" @default.
- W3173125984 startingPage "1071" @default.
- W3173125984 abstract "Development of antidrug antibodies (ADAs) is an undesirable potential outcome of administration of biotherapeutics and involves the innate and adaptive immune systems. ADAs can have detrimental clinical consequences: they can reduce biotherapeutic efficacy or produce adverse events. Because animal models are considered poor predictors of immunogenicity in humans, in vitro assays with human innate and adaptive immune cells are commonly used alternatives that can reveal cell-mediated unwanted immune responses. Multiple methods have been developed to assess the immune cell response following exposure to biotherapeutics and estimate the potential immunogenicity of biotherapeutics. This review highlights the role of innate and adaptive immune cells as the drivers of immunogenicity and summarizes the use of these cells in assays to predict clinical ADA." @default.
- W3173125984 created "2021-06-22" @default.
- W3173125984 creator A5005113575 @default.
- W3173125984 creator A5047150251 @default.
- W3173125984 date "2021-07-01" @default.
- W3173125984 modified "2023-10-16" @default.
- W3173125984 title "In vitro immunogenicity prediction: bridging between innate and adaptive immunity" @default.
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- W3173125984 doi "https://doi.org/10.4155/bio-2021-0077" @default.
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