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- W3173127719 endingPage "e1009127" @default.
- W3173127719 startingPage "e1009127" @default.
- W3173127719 abstract "During meiosis I, ring-shaped cohesin complexes play important roles in aiding the proper segregation of homologous chromosomes. RAD21L is a meiosis-specific vertebrate cohesin that is required for spermatogenesis in mice but is dispensable for oogenesis in young animals. The role of this cohesin in other vertebrate models has not been explored. Here, we tested if the zebrafish homolog Rad21l1 is required for meiotic chromosome dynamics during spermatogenesis and oogenesis. We found that Rad21l1 localizes to unsynapsed chromosome axes. It is also found between the axes of the mature tripartite synaptonemal complex (SC) in both sexes. We knocked out rad21l1 and found that nearly all rad21l1-/- mutants develop as fertile males, suggesting that the mutation causes a defect in juvenile oogenesis, since insufficient oocyte production triggers female to male sex reversal in zebrafish. Sex reversal was partially suppressed by mutation of the checkpoint gene tp53, suggesting that the rad21l1 mutation activates Tp53-mediated apoptosis or arrest in females. This response, however, is not linked to a defect in repairing Spo11-induced double-strand breaks since deletion of spo11 does not suppress the sex reversal phenotype. Compared to tp53 single mutant controls, rad21l1-/- tp53-/- double mutant females produce poor quality eggs that often die or develop into malformed embryos. Overall, these results indicate that the absence of rad21l1-/- females is due to a checkpoint-mediated response and highlight a role for a meiotic-specific cohesin subunit in oogenesis but not spermatogenesis." @default.
- W3173127719 created "2021-06-22" @default.
- W3173127719 creator A5001011973 @default.
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- W3173127719 date "2021-06-17" @default.
- W3173127719 modified "2023-10-15" @default.
- W3173127719 title "Rad21l1 cohesin subunit is dispensable for spermatogenesis but not oogenesis in zebrafish" @default.
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- W3173127719 doi "https://doi.org/10.1371/journal.pgen.1009127" @default.
- W3173127719 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8291703" @default.
- W3173127719 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34138874" @default.
- W3173127719 hasPublicationYear "2021" @default.
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