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- W3173176958 abstract "Adults respond well to antidepressant drugs acting on the noradrenergic system, .e.g., desipramine (DMI), but children generally do not. To determine if this differential response was correlated with an altered alpha-2 adrenergic functional response to DMI treatment, the hypothermic effect of the alpha-2 agonist, brimonidine was compared in juvenile (post-natal day 13) and adult rats. Rats were treated for four days with DMI with the dose given to the juveniles (6 mg/kg/day) adjusted to give brain concentrations comparable to those in adult rats (20 mg/kg/day). Brimonidine, an alpha-2 adrenergic receptor agonist, induced a hypothermic response in control rats at both age groups that could be blocked by the alpha-2 antagonist, RX821002. DMI treated adult, but not juvenile, rats demonstrated an enhanced hypothermic response (p < 0.002) when brimonidine was given at a time point where over 95% of the DMI had cleared from the brain. These results support the concept that children and juvenile rats do not respond well to tricyclic antidepressants because the mechanisms regulating the alpha-2 adrenergic receptor are not fully developed. Research supported by MH64772." @default.
- W3173176958 created "2021-07-05" @default.
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- W3173176958 date "2007-01-01" @default.
- W3173176958 modified "2023-09-24" @default.
- W3173176958 title "Differential alpha‐2 adrenergic functional response in juvenile versus adult rats treated with the tricyclic antidepressant desipramine" @default.
- W3173176958 doi "https://doi.org/10.1096/fasebj.21.6.a783-d" @default.
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