FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3173185463> ?p ?o ?g. }

• W3173185463 abstract "This study aimed to build a mathematical model describing the pharmacokinetics of ticagrelor and its active metabolite (AR-C124910XX) in a stable setting with concomitant administration of morphine. The model consists of a set of four differential equations prepared upon the available knowledge regarding the biological processes in the pharmacokinetics of ticagrelor. The set of equations was solved numerically using the Runge–Kutta method. The data were obtained in a double-blind, randomized, placebo-controlled, crossover trial. Twenty-four healthy volunteers received a 180-mg ticagrelor loading dose together with either 5-mg morphine or placebo. Blood samples were analyzed with liquid chromatography–tandem mass spectrometry to assess plasma concentrations of ticagrelor and AR-C124910XX before ticagrelor loading dose and after that 1, 2, 3, 4, and 6 h. The model allowed us to reproduce the experimental results accurately and led us to conclusions consistent with clinical observations that morphine delays the time of maximum drug concentration and that the morphine effect occurs due to decreased gastrointestinal motility. Based on the model, we were able to predict the effect of drug dose on receptor blocking efficacy." @default.
• W3173185463 created "2021-07-05" @default.
• W3173185463 creator A5004868423 @default.
• W3173185463 creator A5014420240 @default.
• W3173185463 creator A5029816829 @default.
• W3173185463 creator A5064825281 @default.
• W3173185463 creator A5067935886 @default.
• W3173185463 creator A5079576359 @default.
• W3173185463 creator A5080941679 @default.
• W3173185463 date "2021-06-24" @default.
• W3173185463 modified "2023-10-01" @default.
• W3173185463 title "Pharmacokinetic Modeling of Morphine’s Effect on Plasma Concentrations of Ticagrelor and Its Metabolite in Healthy Volunteers" @default.
• W3173185463 cites W1820530960 @default.
• W3173185463 cites W1930765773 @default.
• W3173185463 cites W1964095283 @default.
• W3173185463 cites W2019628996 @default.
• W3173185463 cites W2026997625 @default.
• W3173185463 cites W2068426257 @default.
• W3173185463 cites W2079197876 @default.
• W3173185463 cites W2091107667 @default.
• W3173185463 cites W2121178468 @default.
• W3173185463 cites W2137746198 @default.
• W3173185463 cites W2160678403 @default.
• W3173185463 cites W2162222500 @default.
• W3173185463 cites W2163050713 @default.
• W3173185463 cites W2171354489 @default.
• W3173185463 cites W2214579191 @default.
• W3173185463 cites W2324292926 @default.
• W3173185463 cites W2336070662 @default.
• W3173185463 cites W2412874494 @default.
• W3173185463 cites W2443293408 @default.
• W3173185463 cites W2618031757 @default.
• W3173185463 cites W2752033985 @default.
• W3173185463 cites W2754054868 @default.
• W3173185463 cites W2761014066 @default.
• W3173185463 cites W2805772745 @default.
• W3173185463 cites W2885658558 @default.
• W3173185463 cites W2900070031 @default.
• W3173185463 cites W2920082292 @default.
• W3173185463 cites W2935153017 @default.
• W3173185463 cites W4211214267 @default.
• W3173185463 doi "https://doi.org/10.3389/fphys.2021.663170" @default.
• W3173185463 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8264498" @default.
• W3173185463 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34248659" @default.
• W3173185463 hasPublicationYear "2021" @default.
• W3173185463 type Work @default.
• W3173185463 sameAs 3173185463 @default.
• W3173185463 citedByCount "4" @default.
• W3173185463 countsByYear W31731854632022 @default.
• W3173185463 countsByYear W31731854632023 @default.
• W3173185463 crossrefType "journal-article" @default.
• W3173185463 hasAuthorship W3173185463A5004868423 @default.
• W3173185463 hasAuthorship W3173185463A5014420240 @default.
• W3173185463 hasAuthorship W3173185463A5029816829 @default.
• W3173185463 hasAuthorship W3173185463A5064825281 @default.
• W3173185463 hasAuthorship W3173185463A5067935886 @default.
• W3173185463 hasAuthorship W3173185463A5079576359 @default.
• W3173185463 hasAuthorship W3173185463A5080941679 @default.
• W3173185463 hasBestOaLocation W31731854631 @default.
• W3173185463 hasConcept C111113717 @default.
• W3173185463 hasConcept C112705442 @default.
• W3173185463 hasConcept C126322002 @default.
• W3173185463 hasConcept C142724271 @default.
• W3173185463 hasConcept C149151106 @default.
• W3173185463 hasConcept C185592680 @default.
• W3173185463 hasConcept C204787440 @default.
• W3173185463 hasConcept C27081682 @default.
• W3173185463 hasConcept C2777389121 @default.
• W3173185463 hasConcept C2777477808 @default.
• W3173185463 hasConcept C2777628954 @default.
• W3173185463 hasConcept C2777849778 @default.
• W3173185463 hasConcept C2780890252 @default.
• W3173185463 hasConcept C71924100 @default.
• W3173185463 hasConcept C87813604 @default.
• W3173185463 hasConcept C98274493 @default.
• W3173185463 hasConceptScore W3173185463C111113717 @default.
• W3173185463 hasConceptScore W3173185463C112705442 @default.
• W3173185463 hasConceptScore W3173185463C126322002 @default.
• W3173185463 hasConceptScore W3173185463C142724271 @default.
• W3173185463 hasConceptScore W3173185463C149151106 @default.
• W3173185463 hasConceptScore W3173185463C185592680 @default.
• W3173185463 hasConceptScore W3173185463C204787440 @default.
• W3173185463 hasConceptScore W3173185463C27081682 @default.
• W3173185463 hasConceptScore W3173185463C2777389121 @default.
• W3173185463 hasConceptScore W3173185463C2777477808 @default.
• W3173185463 hasConceptScore W3173185463C2777628954 @default.
• W3173185463 hasConceptScore W3173185463C2777849778 @default.
• W3173185463 hasConceptScore W3173185463C2780890252 @default.
• W3173185463 hasConceptScore W3173185463C71924100 @default.
• W3173185463 hasConceptScore W3173185463C87813604 @default.
• W3173185463 hasConceptScore W3173185463C98274493 @default.
• W3173185463 hasLocation W31731854631 @default.
• W3173185463 hasLocation W31731854632 @default.
• W3173185463 hasOpenAccess W3173185463 @default.
• W3173185463 hasPrimaryLocation W31731854631 @default.
• W3173185463 hasRelatedWork W1830946878 @default.
• W3173185463 hasRelatedWork W1930765773 @default.
• W3173185463 hasRelatedWork W1964759623 @default.
• W3173185463 hasRelatedWork W1976890451 @default.
• W3173185463 hasRelatedWork W2081460129 @default.

• next