FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3173192141> ?p ?o ?g. }

• W3173192141 abstract "Identification of neurons undergoing plasticity in response to external stimuli is one of the pertinent problems in neuroscience. Immediate early genes (IEGs) are widely used as a marker for neuronal plasticity. Here, we model the dynamics of IEG expression as a consecutive, irreversible first-order reaction with a limiting substrate. First, we develop an analytical framework to show that such a model, together with two-photon in vivo imaging of IEG expression, can be used to identify distinct neuronal subsets representing multiple memories. Using the above combination, we show that the expression kinetics, rather than intensity threshold, can be used to identify neuronal ensembles responding to the presentation of two events in vivo. The analytical expression allowed us to segregate the neurons based on their temporal response to one specific behavioural event, thereby improving the ability to detect plasticity related neurons. We image the retrosplenial cortex (RSc) of cfos-GFP transgenic mice to follow the dynamics of cellular changes resulting from contextual fear conditioning behaviour, enabling us to establish a representation of context in RSc at the cellular scale following memory acquisition. Thus, we obtain a general method that distinguishes neurons that took part in multiple temporally separated events by measuring fluorescence of individual neurons in live mice." @default.
• W3173192141 created "2021-07-05" @default.
• W3173192141 creator A5035499609 @default.
• W3173192141 creator A5042558126 @default.
• W3173192141 creator A5068455971 @default.
• W3173192141 date "2021-06-29" @default.
• W3173192141 modified "2023-10-15" @default.
• W3173192141 title "In vivo imaging of immediate early gene expression dynamics segregates neuronal ensemble of memories of dual events" @default.
• W3173192141 cites W1509990832 @default.
• W3173192141 cites W1514059962 @default.
• W3173192141 cites W1584279891 @default.
• W3173192141 cites W1591199750 @default.
• W3173192141 cites W1607671357 @default.
• W3173192141 cites W1928260425 @default.
• W3173192141 cites W1971959365 @default.
• W3173192141 cites W1973490159 @default.
• W3173192141 cites W2003102216 @default.
• W3173192141 cites W2011094102 @default.
• W3173192141 cites W2015252454 @default.
• W3173192141 cites W2038171794 @default.
• W3173192141 cites W2055854037 @default.
• W3173192141 cites W2064371703 @default.
• W3173192141 cites W2079168249 @default.
• W3173192141 cites W2082235945 @default.
• W3173192141 cites W2100985468 @default.
• W3173192141 cites W2104221788 @default.
• W3173192141 cites W2104742248 @default.
• W3173192141 cites W2111354960 @default.
• W3173192141 cites W2119630138 @default.
• W3173192141 cites W2126895376 @default.
• W3173192141 cites W2132708818 @default.
• W3173192141 cites W2142635246 @default.
• W3173192141 cites W2156954346 @default.
• W3173192141 cites W2162407586 @default.
• W3173192141 cites W2168136532 @default.
• W3173192141 cites W2168767109 @default.
• W3173192141 cites W2404947714 @default.
• W3173192141 cites W2513986326 @default.
• W3173192141 cites W2521460688 @default.
• W3173192141 cites W2722019070 @default.
• W3173192141 cites W2754761896 @default.
• W3173192141 cites W2783292933 @default.
• W3173192141 cites W2799343886 @default.
• W3173192141 cites W2897299948 @default.
• W3173192141 cites W2998470023 @default.
• W3173192141 cites W3043084155 @default.
• W3173192141 doi "https://doi.org/10.1186/s13041-021-00798-3" @default.
• W3173192141 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8243579" @default.
• W3173192141 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34187543" @default.
• W3173192141 hasPublicationYear "2021" @default.
• W3173192141 type Work @default.
• W3173192141 sameAs 3173192141 @default.
• W3173192141 citedByCount "7" @default.
• W3173192141 countsByYear W31731921412021 @default.
• W3173192141 countsByYear W31731921412022 @default.
• W3173192141 countsByYear W31731921412023 @default.
• W3173192141 crossrefType "journal-article" @default.
• W3173192141 hasAuthorship W3173192141A5035499609 @default.
• W3173192141 hasAuthorship W3173192141A5042558126 @default.
• W3173192141 hasAuthorship W3173192141A5068455971 @default.
• W3173192141 hasBestOaLocation W31731921411 @default.
• W3173192141 hasConcept C104317684 @default.
• W3173192141 hasConcept C118403218 @default.
• W3173192141 hasConcept C150194340 @default.
• W3173192141 hasConcept C151730666 @default.
• W3173192141 hasConcept C15744967 @default.
• W3173192141 hasConcept C169760540 @default.
• W3173192141 hasConcept C169900460 @default.
• W3173192141 hasConcept C2777348757 @default.
• W3173192141 hasConcept C2779343474 @default.
• W3173192141 hasConcept C2779555244 @default.
• W3173192141 hasConcept C2780200011 @default.
• W3173192141 hasConcept C47611674 @default.
• W3173192141 hasConcept C55493867 @default.
• W3173192141 hasConcept C7033854 @default.
• W3173192141 hasConcept C74254510 @default.
• W3173192141 hasConcept C86803240 @default.
• W3173192141 hasConceptScore W3173192141C104317684 @default.
• W3173192141 hasConceptScore W3173192141C118403218 @default.
• W3173192141 hasConceptScore W3173192141C150194340 @default.
• W3173192141 hasConceptScore W3173192141C151730666 @default.
• W3173192141 hasConceptScore W3173192141C15744967 @default.
• W3173192141 hasConceptScore W3173192141C169760540 @default.
• W3173192141 hasConceptScore W3173192141C169900460 @default.
• W3173192141 hasConceptScore W3173192141C2777348757 @default.
• W3173192141 hasConceptScore W3173192141C2779343474 @default.
• W3173192141 hasConceptScore W3173192141C2779555244 @default.
• W3173192141 hasConceptScore W3173192141C2780200011 @default.
• W3173192141 hasConceptScore W3173192141C47611674 @default.
• W3173192141 hasConceptScore W3173192141C55493867 @default.
• W3173192141 hasConceptScore W3173192141C7033854 @default.
• W3173192141 hasConceptScore W3173192141C74254510 @default.
• W3173192141 hasConceptScore W3173192141C86803240 @default.
• W3173192141 hasFunder F4320320717 @default.
• W3173192141 hasFunder F4320320719 @default.
• W3173192141 hasFunder F4320320721 @default.
• W3173192141 hasFunder F4320334771 @default.
• W3173192141 hasIssue "1" @default.
• W3173192141 hasLocation W31731921411 @default.
• W3173192141 hasLocation W31731921412 @default.

• next