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- W3173229627 abstract "The effects of changes in total protein intake (PRO) on oral glucose tolerance (GT) and lipid-lipoprotein profile (LLP) were studied in 136 overweight/obese 35–65y, free feeding adults who consumed supplements with 400 kcal/d and 0, 20, 40 or 60 g/d whey protein and exercised 3d/week for 9 months. Retrospectively, subjects were divided into impaired GT (baseline 2-h glucose > 140 mg/dL) and normal GT groups. Insulin sensitivity was assessed by the Homeostatic Model Assessment (HOMA: 405/(glucosef (mg/dL) • insulinf (U/L)). A multiple regression model assessed the moderating effects of impaired GT on the impact of change in PRO on the GT, HOMA and LLP parameters (adjusted for weight change and gender). A change in PRO was positively associated with changes in HOMA, fasting triacylglycerol (p<0.05) and fasting insulin (p=0.060) in the GT impaired group only (group by PRO, p < 0.05, < 0.05 and 0.061). Change in PRO was not associated with changes in glucose and insulin responses to a 75-g oral glucose tolerance challenge, or changes in total cholesterol and HDL. In summary, while most research has focused on the effects of total protein intake on health-related outcomes, these results indicate that the change in protein intake is also important to consider when helping overweight/obese adults with impaired glucose tolerance improve their health. Support: US Whey Protein Res Consort; NIH T32AG025671 and UL1 RR025761" @default.
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- W3173229627 date "2012-04-01" @default.
- W3173229627 modified "2023-10-15" @default.
- W3173229627 title "Changes in dietary protein intake differentially affect glucose tolerance and lipid profile in adults with impaired versus normal glucose tolerance" @default.
- W3173229627 doi "https://doi.org/10.1096/fasebj.26.1_supplement.819.15" @default.
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